三聚氟氰

• 产品号: A15666
• CAS号: 675-14-9
• 分子式: C3F3N3
• 分子量: 135.0474096
• 纯 度: 98%

产品别名

• 标题: Cyanuric fluoride
• IUPAC标准名: trifluoro-1,3,5-triazine
• IUPAC传统名: cyanuric fluoride
• 别名: 2,4,6-Trifluoro-1,3,5-triazine

产品登记号

• EC号: 211-620-8
• MDL号: MFCD00014597
• Beilstein号: 124237
• CAS号: 675-14-9

产品性质

• 纯度: 98%
• 沸点: 73-74°C
• 密度: 1.574
• 熔点: -38°C
• 折射率: 1.3840
• GHS危险声明: H310-H330-H314-H318
• 欧盟危险性物质标志: 剧毒(Highly toxic) (T+)
• GHS警示性声明: P260-P303+P361+P353-P304+P340-P305+P351+P338-P320-P361-P405-P501A
• 危险公开号: 24-26-35
• RTECS编号: XZ1750000
• 安全公开号: 20-26-27/28-36/37/39-45
• 保存注意事项: Moisture Sensitive
• TSCA收录: 是
• 联合国危险货物等级: 6.1
• 联合国危险货物编号: UN3389
• 联合国危险货物包装类别(PG): I

参考文献

• In combination with pyridine, converts carboxylic acids to acyl fluorides in high yields under mild conditions: Synthesis, 487 (1973). Similarly, protected (Fmoc) amino acids are converted in dichloromethane solution to amino acid fluorides. tert-Butyl ester and ether groups are also stable under these conditions. The resulting acyl fluorides are more stable to water than the corresponding acyl chlorides but are more reactive to amines, thus providing a useful peptide coupling method: J. Am. Chem. Soc., 112, 9651 (1990); Tetrahedron, 50, 5309 (1994); Appendix 6. For use of Fmoc amino acid fluorides in solid-phase peptide synthesis, see: Tetrahedron Lett., 32, 1303 (1991); J. Org. Chem., 59, 3275 (1994). For a review of peptide synthesis via amino acid halides, see: Acc. Chem. Res., 29, 268 (1996).
• Carboxylic acids can be converted to alcohols under mild conditions via the acyl fluoride and reduction with NaBH₄ in the presence of MeOH. The method can be carried out in one pot and is applicable to N-protected amino acids and peptides for which other reduction methods are unsuitable: J. Org. Chem., 61, 6994 (1996).
• Reagent for deoxygenation of alkyl sulfoxides, cf Cyanuric chloride, L03442: Synthesis, 221 (1980), and for dehydration, at room temperature in DMF, of Boc amino acid amides to nitriles: Tetrahedron. Lett., 38, 4221 (1997).