二甲基苯基氯硅烷

• 产品号: A15638
• CAS号: 768-33-2
• 分子式: C8H11ClSi
• 分子量: 170.71144
• 纯 度: 97+%

产品别名

• 标题: Chlorodimethylphenylsilane
• IUPAC标准名: chlorodimethylphenylsilane
• IUPAC传统名: chlorodimethylphenylsilane
• 别名: Dimethylphenylsilyl chloride; Dimethylphenylchlorosilane

产品登记号

• EC号: 212-193-0
• MDL号: MFCD00000499
• Beilstein号: 606292
• CAS号: 768-33-2

产品性质

• 纯度: 97+%
• 沸点: 192-193°C
• 密度: 1.032
• 闪点: 72°C(161°F)
• 折射率: 1.5090
• GHS危险声明: H314-H318-H227
• 欧盟危险性物质标志: 腐蚀性(Corrosive) (C)
• GHS警示性声明: P210-P260-P303+P361+P353-P305+P351+P338-P405-P501A
• 危险公开号: 34
• 安全公开号: 26-36/37/39-45
• 保存注意事项: Moisture Sensitive
• TSCA收录: 是
• 联合国危险货物等级: 8
• 联合国危险货物编号: UN2987
• 联合国危险货物包装类别(PG): II

参考文献

• See also: J. Chem. Soc., Perkin 1, 1209 (1998).
• Silylating agent (see Appendix 4): J. Chromat., 147, 291 (1978). Dimethylphenylsilyl (DMPS) ethers are somewhat more resistant to hydrolysis than TMS and are useful in the chromatographic analysis of monosaccharides with UV detection: J. Chromat., 264, 99 (1983); Carbohydr. Res., 119, 241 (1983). See also Dimethylphenylsilane, L04558. The lithio-derivatives of esters and lactones are silylated by DMPSCl on carbon (TMSCl gives O-silylation): J. Am. Chem. Soc., 103, 2418 (1981).
• The reactions of various metallated DMPS derivatives have been extensively studied by Fleming's group and others. DMPSLi gives an organocopper species with CuI which undergoes conjugate addition to enones, to give ?-silyl ketones: J. Chem. Soc., Perkin 1., 2520 (1981):
  
• For a study of diastereoselectivity in the preparation of ?-silyl esters from ɑ?-unsaturated esters and amides attached to chiral auxiliaries, see: J. Chem. Soc., Perkin 1, 303 (1995). For a brief feature on Phenyldimethylsilyllithium, see: Synlett, 1522 (2000).
• The DMPS group attached to carbon may function as a masked OH group. Protodesilylation gives the silyl fluoride, which can be converted to the alcohol with overall retention of configuration by reaction with m-CPBA, peracetic acid/Br₂, or peracetic acid/Mg(OAc)₂ with or without Pd(II) catalysis. For a detailed study, see: J. Chem. Soc., Perkin 1, 317 (1995):
  
• Aryl-, alkenyl- and alkynyldimethylchlorosilanes undergo homo-coupling in the presence of TBAF and a catalytic amount of CuI to give biaryls or the corresponding symmetrical dienes or diynes in high yield: J. Chem. Soc., Perkin 1, 797 (1997).