4-甲氧基苄醇

• 产品号: A15559
• CAS号: 105-13-5
• 分子式: C8H10O2
• 分子量: 138.1638
• 纯 度: 98%

产品别名

• 标题: 4-Methoxybenzyl alcohol
• IUPAC标准名: (4-methoxyphenyl)methanol
• IUPAC传统名: P-methoxybenzyl alcohol
• 别名: p-Anisyl alcohol; 4-Methoxyphenylmethanol

产品登记号

• MDL号: MFCD00004653
• CAS号: 105-13-5
• Beilstein号: 636654
• EC号: 203-273-6
• 默克索引号: 14604

产品性质

• 纯度: 98%
• 沸点: 259°C
• 密度: 1.110
• 闪点: 113°C(235°F)
• 熔点: 22-25°C
• 折射率: 1.5450
• GHS危险声明: H301-H315-H319-H335
• 欧盟危险性物质标志: X
• GHS警示性声明: P261-P301+P310-P305+P351+P338-P302+P352-P405-P501A
• 危险公开号: 22-36/37/38
• RTECS编号: DO8925000
• 安全公开号: 26-36/37
• TSCA收录: 是

参考文献

• Carboxyl protection agent giving the 4-methoxybenzyl (PMB; 4-methoxyphenylmethyl; MPM) ester, e.g. by reaction with the 4-nitrophenyl ester. The group is stable to 0.5N HCl in MeOH which readily cleaves Boc groups, but can be removed by TFA, leaving Cbz-groups unaffected: Austr. J. Chem., 21, 2543 (1968). For cleavage using AcOH at 90^o, see: Synth. Commun., 24, 1151 (1994). For cleavage with Cerium(III) chloride heptahydrate, A12947, in the presence of NaI, see: J. Org. Chem., 64, 5696 (1999). See Appendix 6.
• Has also been used, in the presence of TFA, to protect thiols: Tetrahedron Lett., 35, 1631 (1994). Cleavage is by refluxing with TFA: Bull. Chem. Soc. Jpn., 37, 433 (1964); Bioorg. Chem. Med. Lett., 3, 739 (1993), or Hg(II) salts: Chem. Pharm. Bull., 26, 1576 (1978); J. Med. Chem., 31, 2199 (1988); J. Org. Chem., 52, 4420 (1987).