4-硝基溴苄

• 产品号: A15236
• CAS号: 100-11-8
• 分子式: C7H6BrNO2
• 分子量: 216.03204
• 纯 度: 97+%

产品别名

• 标题: 4-Nitrobenzyl bromide
• IUPAC标准名: 1-(bromomethyl)-4-nitrobenzene
• IUPAC传统名: nitrobenzyl bromide
• 别名: alpha-Bromo-4-nitrotoluene

产品登记号

• MDL号: MFCD00007373
• Beilstein号: 742796
• EC号: 202-820-6
• CAS号: 100-11-8

产品性质

• 纯度: 97+%
• 熔点: 97-101°C
• GHS危险声明: H314-H318
• 欧盟危险性物质标志: 腐蚀性(Corrosive) (C)
• GHS警示性声明: P260-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501A
• 危险公开号: 34
• RTECS编号: XS7967000
• 安全公开号: 26-36/37/39-45
• TSCA收录: 是
• 联合国危险货物等级: 8
• 联合国危险货物编号: UN3261
• 联合国危险货物包装类别(PG): II

参考文献

• Has been used as a protecting reagent for the carboxyl group in peptide synthesis: Helv. Chim. Acta, 42, 972 (1959); see 4-Nitrobenzyl chloride, A15749, and Appendix 6. Has also been used in ?-lactam synthesis. Cleavage by sodium sulfide avoids hydrogenolysis problems otherwise encountered with these sulfur-containing nuclei: J. Org. Chem., 43, 1243 (1978).
• For the protection of alcohols, introduction of the group by the use of silver oxide has been recommended. Selective cleavage can be accomplished with DDQ (2,3-Dichloro-5,6-dicyanobenzoquinone, A11879) or by anodic oxidation. Many other benzyl-type protecting groups are unaffected by these conditions: Tetrahedron Lett., 31, 389 (1990). Indium metal in the presence of ammonium chloride is an effective deprotection system for 4-nitrobenzyl ethers and esters: J. Chem. Soc., Perkin 1, 955 (2001).