三甲基乙酰氯

• 产品号: A15051
• CAS号: 3282-30-2
• 分子式: C5H9ClO
• 分子量: 120.57736
• 纯 度: 98+%

产品别名

• 标题: Trimethylacetyl chloride
• IUPAC标准名: 2,2-dimethylpropanoyl chloride
• IUPAC传统名: 2,2-dimethylpropanoyl chloride
• 别名: Pivaloyl chloride

产品登记号

• Beilstein号: 385668
• CAS号: 3282-30-2
• MDL号: MFCD00000709
• EC号: 221-921-6

产品性质

• 纯度: 98+%
• 沸点: 105-106°C
• 密度: 0.985
• 闪点: 8°C(46°F)
• 熔点: -57°C
• 折射率: 1.4120
• GHS危险声明: H225-H301-H330-H314-H318
• 欧盟危险性物质标志: 剧毒(Highly toxic) (T+)
• 欧盟危险性物质标志: 易燃性(Flammable) (F)
• GHS警示性声明: P210-P301+P310-P303+P361+P353-P304+P340-P305+P351+P338-P320-P330-P405-P501A
• 危险公开号: 11-14-22-26-34
• 安全公开号: 4-8-9-16-20-23-26-28-30-33-36/37/39-45
• 保存注意事项: Moisture Sensitive
• TSCA收录: 是
• 联合国危险货物等级: 6.1
• 联合国危险货物编号: UN2438
• 联合国危险货物包装类别(PG): I

参考文献

• In the presence of Cu(I) halides, reacts with Grignard and organolithium reagents to give t-butyl ketones: Tetrahedron Lett., 829 (1971).
• Activates heteroaromatic amines to ring-lithiation. For example: Synthesis, 670 (1986):
  
• Reacts with sodium formate to give the mixed formic pivalic anhydride, a highly effective reagent for N-formylation: Rec. Trav. Chim., 101, 460 (1982). Similarly, has been used to form mixed anhydrides, particularly of N-protected amino acids and peptides, prior to coupling: Coll. Czech. Chem. Commun., 27, 1273 (1962). The sterically-hindered nature of the pivaloyl group greatly reduces attack at the 'wrong' carbonyl group. For peptide reagents, see Appendix 6.
• Has also been used as a reagent for protection of alcohols as their pivaloyl (Pv) esters, allowing selective acylation of a primary over a secondary alcohol: Synthesis, 453 (1986); selective protection of the less hindered of two primary alcohols is possible: J. Chem. Soc., Chem. Commun., 354 (1988). See also Trimethylacetic anhydride, B22983. Cleavage is by room temperature basic hydrolysis: Tetrahedron Lett., 317 (1973); 3561 (1979); J. Org. Chem., 42, 918 (1977), or methanolysis: J. Am. Chem. Soc., 112, 3693 (1990), or a number of other methods, including aqueous methylamine: Tetrahedron, 24, 639 (1968).