硝基乙酸乙酯

• 产品号: A14433
• CAS号: 626-35-7
• 分子式: C4H7NO4
• 分子量: 133.10268
• 纯 度: 97%

产品别名

• 标题: Ethyl nitroacetate
• IUPAC标准名: ethyl 2-nitroacetate
• IUPAC传统名: nitroacetic acid ethyl ester
• 别名: Nitroacetic Acid Ethyl Ester

产品登记号

• MDL号: MFCD00007403
• EC号: 210-944-7
• CAS号: 626-35-7
• Beilstein号: 1210027

产品性质

• 纯度: 97%
• 沸点: 93-95°C/10mm
• 密度: 1.202
• 闪点: 92°C(197°F)
• 折射率: 1.4240
• GHS危险声明: H315-H319-H227
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• GHS警示性声明: P280G-P305+P351+P338
• 危险公开号: 36/38
• RTECS编号: AJ1074000
• 安全公开号: 26-37
• TSCA收录: 是

参考文献

• In the presence of the Mitsunobu reagent (PPh₃/DEAD) oxidizes alcohols to carbonyl compounds: Tetrahedron Lett., 22, 2295 (1981).
• For a review of the use of nitroacetic acid and its esters in organic synthesis, see: Synthesis, 666 (1979).
• Reacts with 2,3-epoxyaldehydes to give 3-ethoxycarbonyl-4-hydroxy-5-(1-hydroxyalkyl)-2-isoxazoline-2-oxides: J. Org. Chem., 55, 781 (1990):
  
• Similarly, reaction with ɑ-bromo enones gives 5-acyl-3-(ethoxycarbonyl)-2-isoxazoline-2-oxides by a tandem conjugate addition - ring closure: J. Org. Chem., 60,6624 (1995).
• Conjugate addition to various enones, followed by reductive cyclization with Formamidinesulfinic acid, A11885, provides a convenient new route to pyrroles: Tetrahedron Lett., 36, 9469 (1995). For examples with reaction schemes, see 2-Benzylidenecyclohexanone, L13434 and 3-Penten-2-one, L13031.