2,4-戊烷二酮

• 产品号: A14117
• CAS号: 123-54-6
• 分子式: C5H8O2
• 分子量: 100.11582
• 纯 度: 99%

产品别名

• 标题: 2,4-Pentanedione
• IUPAC标准名: pentane-2,4-dione
• IUPAC传统名: acetylacetone
• 别名: Acetylacetone; AcAc

产品登记号

• MDL号: MFCD00008787
• EC号: 204-634-0
• Beilstein号: 741937
• CAS号: 123-54-6
• 默克索引号: 1481

产品性质

• 纯度: 99%
• 沸点: 140-141°C
• 密度: 0.973
• 闪点: 34°C(93°F)
• 熔点: -23°C
• 折射率: 1.4520
• GHS危险声明: H226-H302
• 欧盟危险性物质标志: X
• GHS警示性声明: P210-P241-P280-P303+P361+P353-P403+P235-P501A
• 危险公开号: 10-22
• RTECS编号: SA1925000
• 安全公开号: 21-23-24/25
• TSCA收录: 是
• 联合国危险货物等级: 3
• 联合国危险货物编号: UN2310
• 联合国危险货物包装类别(PG): III

参考文献

• A simple procedure for the synthesis of methyl ketones involves alkylation at the 3-position with an alkyl halide using K₂CO₃ in EtOH, with in situ acetyl cleavage: Org. Synth. Coll., 5, 767 (1973). Knoevenagel condensation with aldehydes in THF in the presence of K₂CO₃ also occurs with acetyl cleavage, providing a simple route to alkenyl ketones: Chem. Lett., 1325 (1978). With K₂CO₃ and TBAB, selective one-pot monoalkylation or dialkylation with different alkyl groups can be achieved: Synthesis, 688 (1989). 3-Arylation with aryl bromides takes place in the presence of Cu(I) or Cu(II) salts in DMF: Chem. Lett., 597 (1982); Org. Synth. Coll., 6, 36 (1988).
• Strong bases, e.g. NaNH₂, form the dianion which reacts with electrophiles, e.g. alkyl halides, esters, acyl halides, Michael acceptors, etc., at the less-stabilized terminal carbon: J. Org. Chem., 26, 1716 (1961); Tetrahedron Lett., 357 (1970); J. Org. Chem., 39, 2289 (1974); Org. Synth. Coll., 5, 848 (1973). For arylation at the 1-position, see Diphenyliodonium chloride, A15149. For reviews of dimetallation, see: Org. React., 17, 155 (1969); Synthesis, 509 (1977).