4-甲氧基苯磺酰氯

• 产品号: A13788
• CAS号: 98-68-0
• 分子式: C7H7ClO3S
• 分子量: 206.64668
• 纯 度: 98+%

产品别名

• 标题: 4-Methoxybenzenesulfonyl chloride
• IUPAC标准名: 4-methoxybenzene-1-sulfonyl chloride
• IUPAC传统名: 4-methoxybenzenesulfonyl chloride
• 别名: p-Anisolesulfonyl chloride

产品登记号

• EC号: 202-692-1
• Beilstein号: 609005
• MDL号: MFCD00007446
• CAS号: 98-68-0

产品性质

• 纯度: 98+%
• 沸点: 119-122°C/0.4mm
• 闪点: >110°C(230°F)
• 熔点: 37-42°C
• GHS危险声明: H314-H318
• 欧盟危险性物质标志: 腐蚀性(Corrosive) (C)
• GHS警示性声明: P260-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501A
• 危险公开号: 34
• 安全公开号: 26-36/37/39-45
• 保存注意事项: Moisture Sensitive
• TSCA收录: 否
• 联合国危险货物等级: 8
• 联合国危险货物编号: UN3261
• 联合国危险货物包装类别(PG): II

参考文献

• Amines and other N-functions can be protected as 4-methoxybenzenesufonyl (PMBS, Mps) derivatives: Chem. Pharm. Bull., 29, 2592 (1981), useful for the imidazole in histidines, stable to TFA and HBr/AcOH: Bull. Chem. Soc. Jpn., 47, 3146 (1974); J. Org. Chem., 45, 547 (1980); deprotection in TFA is promoted by dimethyl sulfide: J. Chem. Soc., Chem. Commun., 955 (1979). For deprotection of PMBS-indoles using Mg in methanol, see: J. Org. Chem., 62, 6519 (1997).
• Also used for protection of the guanidino function of arginine residues in peptide synthesis. The sulfonamide is cleaved by triflic acid under less drastic conditions than tosyl groups: Chem. Pharm. Bull., 24, 1568 (1976). Compare also 4-Methoxy-2,3,6-trimethylbenzenesulfonyl chloride, L11829. See Appendix 6.