乙氧亚甲基丙二酸二乙酯

• 产品号: A13776
• CAS号: 87-13-8
• 分子式: C10H16O5
• 分子量: 216.23104
• 纯 度: 98+%

产品别名

• 标题: Diethyl ethoxymethylenemalonate
• IUPAC标准名: 1,3-diethyl 2-(ethoxymethylidene)propanedioate
• IUPAC传统名: 1,3-diethyl 2-(ethoxymethylidene)propanedioate
• 别名: Ethoxymethylenepropanedioic acid diethyl ester; Ethoxymethylenemalonic acid diethyl ester

产品登记号

• MDL号: MFCD00009148
• CAS号: 87-13-8
• EC号: 201-725-7
• Beilstein号: 880058

产品性质

• 纯度: 98+%
• 沸点: 136-139°C/10mm
• 密度: 1.080
• 闪点: 144°C(291°F)
• 熔点: -33°C
• 折射率: 1.4620
• GHS危险声明: H334-H315-H319-H317-H303
• 欧盟危险性物质标志: X
• GHS警示性声明: P285-P261-P305+P351+P338-P302+P352-P321-P501A
• 危险公开号: 22-36/38-42/43
• RTECS编号: OO1100000
• 安全公开号: 23-24-26-36/37-45
• TSCA收录: 是

参考文献

• Can be converted to the unstable diethyl methylenemalonate by catalytic reduction and elimination of ethanol on distillation, see: Org. Synth. Coll., 4, 298 (1963).
• Stable equivalent of the ɑ-formylmalonate, valuable synthetic building block, particularly in heterocyclic syntheses. Review: Adv. Het. Chem., 54, (1992).
• Has been used for the protection of the amino group of ɑ-amino acids, allowing clean esterification by O-alkylation. The protecting group can be removed using bromine in chloroform: Synthesis, 544 (1989):
  
• For N-protection of aminoglycosides prior to O-acetylation, see: J. Carbohydr. Chem., 14, 1133 (1995). Chlorine in chloroform at 0^oC was used for deprotection.