氯磷酸二苯酯

• 产品号: A13546
• CAS号: 2524-64-3
• 分子式: C12H10ClO3P
• 分子量: 268.632761
• 纯 度: 97%

产品别名

• 标题: Diphenyl phosphorochloridate
• IUPAC标准名: diphenyl chlorophosphonate
• IUPAC传统名: diphenyl chlorophosphonate
• 别名: Diphenyl chlorophosphate; Diphenyl phosphoryl chloride

产品登记号

• EC号: 219-759-6
• Beilstein号: 654130
• CAS号: 2524-64-3
• MDL号: MFCD00003030

产品性质

• 纯度: 97%
• 沸点: 145-147°C/1mm
• 密度: 1.296
• 闪点: 113°C(235°F)
• 折射率: 1.5500
• GHS危险声明: H314-H318
• 欧盟危险性物质标志: 腐蚀性(Corrosive) (C)
• GHS警示性声明: P260-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501A
• 危险公开号: 34
• 安全公开号: 20-26-36/37/39-45-60
• 保存注意事项: Moisture Sensitive
• TSCA收录: 是
• 联合国危险货物等级: 8
• 联合国危险货物编号: UN3265
• 联合国危险货物包装类别(PG): III

参考文献

• Diphenylphosphate esters, formed with or without catalysis by DMAP, undergo a variety of transformations:
• Hydrogenolysis of the phenyl groups yields the monophosphate ester of the alcohol. Glycosyl monophosphates have been prepared in this way. Alternatively, treatment of the glycosyl diphenyl phosphate with sodium azide in DMF provides a high yield route to glycosyl azides: Carbohydr. Res., 223, 169 (1992).
• Diphenylphosphate has also been exploited as a good leaving group in the high yield conversion (equivalent to dehydration) of secondary alcohols to olefins by thermal elimination: Synthesis, 1300 (1995). For further information, see Triphenyl phosphate, L08130. Other conversions, generally in the presence of a base such as triethylamine, in which the equivalent of a dehydration step occurs are:
• Aldoximes to nitriles at room temperature: J. Org. Chem., 34, 2805 (1969). Peptide coupling (see Appendix 6), via the mixed carboxyl phosphate anhydride: Chem. Ber., 94, 2644 (1961). Carboxylic acids to anhydrides: Synthesis, 219 (1981). ω-Hydroxy acids to macrolides, promoted by DMAP: J. Org. Chem., 47, 1612 (1982).
• Lithium enolates give enol diphenylphosphates in which the phosphate moiety acts as a leaving group; e.g., ketone enol phosphates have been converted to the corresponding alkene by reaction with organocuprates: Tetrahedron Lett., 4405 (1976). With amides, internal displacement occurs; subsequent reaction with NaN₃ gives azirines: Helv. Chim. Acta, 76, 2830 (1993):
  
• See also Diphenylphosphonic azide, A12124.