叔丁基二甲基氯硅烷

• 产品号: A13064
• CAS号: 18162-48-6
• 分子式: C6H15ClSi
• 分子量: 150.7218
• 纯 度: 97%

产品别名

• 标题: tert-Butyldimethylchlorosilane
• IUPAC标准名: tert-butyl(chloro)dimethylsilane
• IUPAC传统名: t-butyldimethylchlorosilane
• 别名: tert-Butyldimethylsilyl chloride; tert-Butylchlorodimethylsilane

产品登记号

• EC号: 242-042-4
• CAS号: 18162-48-6
• MDL号: MFCD00000501
• Beilstein号: 505999

产品性质

• 纯度: 97%
• 沸点: 124-126°C
• 密度: 0.81
• 闪点: 22°C(72°F)
• 熔点: 86-89°C
• GHS危险声明: H228-H314-H318
• 欧盟危险性物质标志: 腐蚀性(Corrosive) (C)
• 欧盟危险性物质标志: 易燃性(Flammable) (F)
• GHS警示性声明: P210-P280-P305+P351+P338-P309-P310
• 危险公开号: 11-34
• RTECS编号: VV2000000
• 安全公开号: 16-26-36/37/39-45
• 保存注意事项: Moisture Sensitive
• TSCA收录: 是
• 联合国危险货物等级: 4.1
• 联合国危险货物编号: UN2925
• 联合国危险货物包装类别(PG): II

参考文献

• Reagent for silylation of hydroxyl functions (see Appendix 4), giving silyl ethers more stable to aqueous hydrolysis e.g. during work-up, than TMS. Various conditions have been used for the introduction of the group:
• Imidazole in DMF: J. Am. Chem. Soc., 94, 6190 (1972); Et₃N - DMAP: Tetrahedron Lett., 99 (1979); Org. Synth. Coll., 9, 136 (1998); N-ethyldiisopropylamine: Tetrahedron Lett., 25, 227 (1984); 1,1,3,3-tetramethylguanidine: J. Org. Chem., 49, 4657 (1984); K₂CO₃ (phase-transfer): Synth. Commun., 11, 545 (1981); DBU - superior to imidazole for thiols, amines and carboxylic acids: Tetrahedron Lett., 26, 475 (1985).
• Cleavage is generally effected with fluoride ion e.g. TBAF in an aprotic system: J. Am. Chem. Soc., 94, 6190 (1972), or KF with a phase-transfer catalyst: J. Am. Chem. Soc., 90, 4462, 4464 (1968); 96, 2250 (1974); J. Chem. Soc., Chem. Commun., 514 (1979).
• Acidic ion-exchange resin: Tetrahedron Lett., 21, 137 (1980); NBS in DMSO: Synthesis, 234 (1980); BF₃ etherate: Synth. Commun., 9, 295 (1979); FeCl₃ or SnCl₂ in acetonitrile: Synth. Commun., 20, 757 (1990); K 10 clay in aqueous methanol: J. Org. Chem.61, 9026 (1996); DMSO-water at 90^o; many other groups unaffected: Tetrahedron Lett., 38, 495 (1997). See also Pyridinium p-toluenesulfonate, A15708, and Triethylamine trihydrofluoride, L14417.
• Many other reagents have been used, including: