苯甲醚

• 产品号: A12997
• CAS号: 100-66-3
• 分子式: C7H8O
• 分子量: 108.13782
• 纯 度: 99%

产品别名

• 标题: Anisole
• IUPAC标准名: anisole
• IUPAC传统名: anisole
• 别名: Methyl phenyl ether; Methoxybenzene

产品登记号

• Beilstein号: 506892
• CAS号: 100-66-3
• MDL号: MFCD00008354
• 默克索引号: 14669
• EC号: 202-876-1

产品性质

• 纯度: 99%
• 沸点: 153-154°C
• 密度: 0.994
• 闪点: 43°C(109°F)
• 熔点: -37°C
• 折射率: 1.5170
• GHS危险声明: H226-H332-H315-H319-H335-H303
• 欧盟危险性物质标志: X
• GHS警示性声明: P210-P241-P303+P361+P353-P305+P351+P338-P405-P501A
• 危险公开号: 10-20-36/37/38
• RTECS编号: BZ8050000
• 安全公开号: 9-23-26-36/37-60
• TSCA收录: 是
• 联合国危险货物等级: 3
• 联合国危险货物编号: UN2222
• 联合国危险货物包装类别(PG): III

参考文献

• The rate of ortho-lithiation of anisole is accelerated dramatically in the presence of TMEDA, effective also in sub-stoichiometric amounts: Tetrahedron Lett., 35, 385 (1994). For discussion of the mechanism of ortho-lithiation, see: J. Org. Chem., 62, 3024 (1997). Although direct dilithiation with n-BuLi/TMEDA was unsuccessful, a sequence involving monolithiation, silylation and further lithiation at the 6-position gave the 2,6-disilyl derivative in 72% yield: J. Org. Chem., 49, 4657 (1984).
• Widely used as a carbocation scavenger in the deblocking of, e.g. N-Boc or N-Cbz (Z) peptides with acidic reagents. Addition of anisole removes t-butyl or benzyl cations from the reaction mixture; see, e.g.: J. Chem. Soc., Chem. Commun., 922 (1976); Chem. Pharm. Bull., 25, 2929 (1977); Chem. Ber., 101, 3649 (1968).