氯乙腈

• 产品号: A12825
• CAS号: 107-14-2
• 分子式: C2H2ClN
• 分子量: 75.49698
• 纯 度: 98+%

产品别名

• 标题: Chloroacetonitrile
• IUPAC标准名: 2-chloroacetonitrile
• IUPAC传统名: chloroacetonitrile

产品登记号

• CAS号: 107-14-2
• MDL号: MFCD00001885
• Beilstein号: 506028
• EC号: 203-467-0

产品性质

• 纯度: 98+%
• 沸点: 124-126°C
• 密度: 1.195
• 闪点: 56°C(132°F)
• 折射率: 1.4230
• GHS危险声明: H301-H311-H331-H226-H411
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• 欧盟危险性物质标志: 环境危害性(Nature polluting) (N)
• GHS警示性声明: P210-P301+P310-P303+P361+P353-P361-P405-P501A
• 危险公开号: 23/24/25-51/53
• RTECS编号: AL8225000
• 安全公开号: 1/2-45-61
• TSCA收录: 是
• 联合国危险货物等级: 6.1
• 联合国危险货物编号: UN2668
• 联合国危险货物包装类别(PG): I

参考文献

• Forms cyanomethyl esters with carboxylic acids, e.g. in the presence of Et₃N, which are a useful protection method; the esters are readily cleaved by Na₂S in aqueous acetone: Synth. Commun., 22, 693 (1992).
• Good yields of ?-hydroxy nitriles have been obtained by Reformatsky-type reaction with aldehydes and ketones using Zn and TMS chloride: Tetrahedron Lett., 31, 2205 (1990). See Bromoacetonitrile, A13933.
• In the presence of base, Darzens condensation with aldehydes and ketones, under conventional or phase-transfer conditions, gives glycidonitriles (cyano epoxides), readily converted to the homologated carboxylic acids, esters or aldehydes with loss of cyanide: J. Chem. Soc., Chem. Commun., 988 (1974); Coll. Czech. Chem. Commun., 53, 822 (1988).
• Ritter reaction with tertiary alcohols yields 2-chloroacetamides which, on treatment with thiourea, provides a high-yield conversion of tertiary alcohols to the corresponding amines: Synthesis, 1709 (2000):
  
• For use in vicarious nucleophilic substitution of hydrogen in nitro-substituted hetereocycles, see 2-Nitrothiophene, A17464.