丙二酸氢乙酯

• 产品号: A12627
• CAS号: 1071-46-1
• 分子式: C5H8O4
• 分子量: 132.11462
• 纯 度: 96%

产品别名

• 标题: Ethyl hydrogen malonate
• IUPAC标准名: 3-ethoxy-3-oxopropanoic acid
• IUPAC传统名: ethyl hydrogen malonate
• 别名: Malonic acid monoethyl ester; Monoethyl malonate

产品登记号

• Beilstein号: 1758845
• EC号: 213-992-7
• CAS号: 1071-46-1
• MDL号: MFCD00020490

产品性质

• 纯度: 96%
• 沸点: 106°C/3mm
• 密度: 1.119
• 闪点: >110°C(230°F)
• 折射率: 1.4295
• GHS危险声明: H315-H319-H335
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• GHS警示性声明: P261-P305+P351+P338-P302+P352-P321-P405-P501A
• 危险公开号: 36/37/38
• 安全公开号: 26-37-60
• TSCA收录: 否

参考文献

• Carbodiimide coupling with polymer-bound ɑ-amino acids has been used in the solid-phase synthesis of substituted tetramic acids; J. Org. Chem., 63, 4808 (1998).
• See also Ethyl potassium malonate, A10720.
• Half esters of malonic acid react with ɑ?-enals in pyridine/DMAP to give ɑ? δ-dienoic esters with good (E)-selectivity: Synthesis: 534 (1988).
• Reaction with alkyl chloroformates results in decarboxylation of the mixed anhydride in situ, providing a route to mixed ethyl alkyl malonates in high yield under very mild conditions: Tetrahedron Lett., 26, 1573 (1985).
• The O,ɑ-dilithio-derivative, formed with n-BuLi in THF, can be acylated with acid chlorides to give, on acidic work-up (in situ decarboxylation), ?-ketoesters directly in high yield: J. Org. Chem., 44, 310 (1979); Org. Synth. Coll., 7, 213 (1990). Similarly, alkylation of the dilithio-derivative provides a direct route to esters of substituted acetic acids: J. Org. Chem., 40, 2556 (1975).