15-冠-5醚

• 产品号: A12265
• CAS号: 33100-27-5
• 分子式: C10H20O5
• 分子量: 220.2628
• 纯 度: 98%

产品别名

• 标题: 15-Crown-5
• IUPAC标准名: 1,4,7,10,13-pentaoxacyclopentadecane
• IUPAC传统名: 15-crown-5 ether
• 别名: 1,4,7,10,13-Pentaoxacyclopentadecane

产品登记号

• EC号: 251-379-6
• CAS号: 33100-27-5
• Beilstein号: 1618144
• MDL号: MFCD00005110

产品性质

• 纯度: 98%
• 沸点: 150-155°C/0.5mm
• 密度: 1.110
• 闪点: >110°C(230°F)
• 折射率: 1.4650
• GHS危险声明: H301-H315-H319-H335
• 欧盟危险性物质标志: X
• GHS警示性声明: P261-P301+P310-P305+P351+P338-P302+P352-P405-P501A
• 危险公开号: 22-36/37/38
• RTECS编号: SB0200000
• 安全公开号: 23-26-36/37
• 保存注意事项: Hygroscopic
• TSCA收录: 是

参考文献

• Crown ether (see Appendix 2) especially suited to complexing sodium ions. Thus, catalyzes the O-alkylation of the Na salts of carboxylic acids in the penicillin and cephalosporin series, providing a method for esterification without exposure to acid: Synthesis, 52, (1986).
• Greatly facilitates the Williamson synthesis of ethers with hindered alcohols and NaH: Tetrahedron Lett., 38, 4679 (1997). Promotes the cleavage of unsymmetrical ethers by Sodium iodide, A15480, in the opposite sense to BBr₃, i.e. by nucleophilic displacement from the less substituted carbon atom: Tetrahedron Lett., 22, 4239 (1981).
• Greatly increases the reactivity of phosphonate anions generated by reaction with NaH in the Horner-Wadsworth-Emmons reaction. Thus, has been used in a high-yield synthesis of stilbenes from aldehydes and Diethyl benzylphosphonate, A10645: Synthesis, 117 (1981).
• Use in combination with Lithium aluminum hydride, A18116, enables reductions to be carried out in hydrocarbon solvents: J. Chem. Soc., Chem. Commun., 1234 (1985).