二甲氧基甲烷

• 产品号: A12055
• CAS号: 109-87-5
• 分子式: C3H8O2
• 分子量: 76.09442
• 纯 度: 98%

产品别名

• 标题: Dimethoxymethane
• IUPAC标准名: dimethoxymethane
• IUPAC传统名: dimethoxymethane
• 别名: Methylal; Formaldehyde dimethyl acetal

产品登记号

• EC号: 203-714-2
• MDL号: MFCD00008495
• 默克索引号: 146012
• CAS号: 109-87-5
• Beilstein号: 1697025

产品性质

• 纯度: 98%
• 沸点: 41-42°C
• 密度: 0.863
• 闪点: -17°C(1°F)
• 熔点: -105°C
• 折射率: 1.3545
• GHS危险声明: H225-H319
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 欧盟危险性物质标志: 易燃性(Flammable) (F)
• GHS警示性声明: P210-P241-P303+P361+P353-P305+P351+P338-P403+P235-P501A
• 危险公开号: 11-36
• RTECS编号: PA8750000
• 安全公开号: 9-16-26
• 保存注意事项: Moisture Sensitive
• TSCA收录: 是
• 联合国危险货物等级: 3
• 联合国危险货物编号: UN1234
• 联合国危险货物包装类别(PG): II

参考文献

• In combination with P₂O₅, protects alcohols as their methoxymethyl (MOM) ethers, usually preferable to methods using carcinogenic methoxymethyl halides: Synthesis, 276 (1975); Org. Synth. Coll., 9, 539 (1998). The MOM group is more effective than the methoxy group in the activation of aromatics to lithiation: Synthesis, 906 (1979). Alternative agents for promoting this acetal exchange include: BF₃ etherate and 4A sieves: Org. Synth. Coll., 9, 704 (1998); tosic acid and molecular sieves: Synthesis, 244 (1976) or LiBr: Synthesis, 74 (1985), or tosic acid itself: Org. Prep. Proced. Int., 22, 63 (1990); Iodotrimethylsilane, A12902: Synthesis, 896 (1983); montmorillonite K 10: Indian J. Chem. B., 35B, 260 (1996); see also Scandium(III) trifluoromethanesulfonate hydrate, 40566. The MOM group is readily cleaved with mild acid, e.g. HCl: J. Chem. Soc., Chem. Commun., 298 (1974); J. Org. Chem., 40, 2025 (1975), PPTS: Synth. Commun., 13, 1021 (1983), TFA: J. Am .Chem. Soc., 103, 3210 (1981), Dowex 50WX2 resin: Synth. Commun., 22, 2823 (1983).
• Has also been used to protect diols as their methylene acetals, using TMS-OTf/2,6-lutidine: Tetrahedron Lett., 26, 4639 (1985), or LiBr/TsOH: Tetrahedron Lett., 28, 6601 (1987).
• Formaldehyde equivalent and low-toxicity solvent for non-acidic materials.
• Can be used in combination with n-hexanoyl chloride for the generation of chloromethyl methyl ether (caution!): J. Org. Chem., 59, 6499 (1994).