甲基苯基砜

• 产品号: A11727
• CAS号: 3112-85-4
• 分子式: C7H8O2S
• 分子量: 156.20222
• 纯 度: 98+%

产品别名

• 标题: Methyl phenyl sulfone
• IUPAC标准名: methanesulfonylbenzene
• IUPAC传统名: sulfone, phenyl, methyl-

产品登记号

• MDL号: MFCD00014741
• Beilstein号: 1906914
• EC号: 221-476-8
• CAS号: 3112-85-4

产品性质

• 纯度: 98+%
• 熔点: 85-88°C
• GHS危险声明: H302
• 欧盟危险性物质标志: X
• GHS警示性声明: P264-P270-P301+P312-P330-P501A
• 危险公开号: 22
• RTECS编号: WR6800000
• 安全公开号: 36
• TSCA收录: 否

参考文献

• Factors governing the selective alkylation have been studied. Lithium bases favor dialkylation. For monoalkylation, a potassium base, e.g. KH in THF, should be used: J. Org. Chem., 55, 2234 (1990).
• Adds to aldehydes and ketones in the presence of base, e.g. n-BuLi, to give ?-hydroxy sulfones. Conversion of the OH to, e.g. to mesylate, and elimination/desulfurative reduction with sodium amalgam provides a 1-substitued or 1,1-disubstituted alkene by the Julia olefination reaction: Tetrahedron Lett., 4833 (1973); J. Chem. Soc., Perkin 1, 829 (1978). For reaction scheme, see Ethyl phenyl sulfone, A10710. The adducts with aldehydes can also be rearranged to give the dimethyl acetals of the homologous aldehydes: J. Chem. Soc., Perkin 1, 1646 (1978). Reaction with acyl halides gives ?-keto sulfones: J. Org. Chem., 53, 906 (1988).