4,4'-二甲氧基三苯基氯甲烷

• 产品号: A11626
• CAS号: 40615-36-9
• 分子式: C21H19ClO2
• 分子量: 338.82736
• 纯 度: 98%

产品别名

• 标题: 4,4'-Dimethoxytrityl chloride
• IUPAC标准名: 1-[chloro(4-methoxyphenyl)benzyl]-4-methoxybenzene
• IUPAC传统名: 1-[chloro(4-methoxyphenyl)benzyl]-4-methoxybenzene
• 别名: 4,4'-Dimethoxytriphenylmethyl chloride; DMT

产品登记号

• EC号: 255-002-6
• Beilstein号: 2471942
• MDL号: MFCD00008409
• CAS号: 40615-36-9

产品性质

• 纯度: 98%
• 熔点: 121-127°C
• GHS危险声明: H315-H319-H335
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• GHS警示性声明: P261-P305+P351+P338-P302+P352-P321-P405-P501A
• 危险公开号: 36/37/38
• 安全公开号: 26-37
• 保存注意事项: Moisture Sensitive
• TSCA收录: 否

参考文献

• Reagent for protection of alcohols, compare Chlorotriphenylmethane, A11799 as their dimethoxytrityl (Dmt) ethers. Mono-, di- and trimethoxytrityl chlorides form ethers of increasing acid-lability, each MeO group increasing the rate of cleavage by ca x10: J. Am. Chem. Soc., 84, 430 (1962); 85, 3821 (1963). The group is introduced e.g. by reaction with the alcohol in pyridine solution. For use of DMAP as catalyst, see: J. Am. Chem. Soc., 104, 1316 (1982), or of silver nitrate: Can. J. Chem., 60, 1106 (1982).
• For selective protection and deprotection procedures for SH and OH groups in nucleoside derivatives, see: Synlett, 83 (1993).
• In a comparison with Mmt for N-protection during solid-phase peptide synthesis, the N-Mmt group was found to survive intact whereas N-Dmt derivatives decomposed slowly in protic solvents: Tetrahedron. Lett., 39, 1733 (1998).
• Selective cleavage in acid-sensitive nucleosides and nucleotides without competing N-glycosyl cleavage has also been accomplished by the use of 1,1,1,3,3,3-Hexafluoro-2-propanol, A12747: Tetrahedron Lett., 36, 7833 (1995). For deprotection with montmorillonite K 10 clay, see: J. Org. Chem., 61, 9026 (1996).