氰基乙酸乙酯

• 产品号: A11498
• CAS号: 105-56-6
• 分子式: C5H7NO2
• 分子量: 113.11458
• 纯 度: 98+%

产品别名

• 标题: Ethyl cyanoacetate
• IUPAC标准名: ethyl 2-cyanoacetate
• IUPAC传统名: ethyl cyanoacetate
• 别名: Cyanoacetic acid ethyl ester

产品登记号

• 默克索引号: 143786
• MDL号: MFCD00001940
• Beilstein号: 605871
• CAS号: 105-56-6
• EC号: 203-309-0

产品性质

• 纯度: 98+%
• 沸点: 208-210°C
• 密度: 1.063
• 闪点: 109°C(228°F)
• 熔点: -23°C
• 折射率: 1.4180
• GHS危险声明: H319
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• GHS警示性声明: P261-P305+P351+P338
• 危险公开号: 36
• RTECS编号: AG4110000
• 安全公开号: 23-26
• TSCA收录: 是

参考文献

• For use in the synthesis of pyrrole derivatives, see p-Toluenesulfonylmethyl isocyanide, A14312.
• Stereoselective alkylation of the active methylene has been accomplished under particularly mild conditions with secondary alkyl mesylates in the presence of CsF in DMF; complete inversion occurs at the secondary alkyl carbon: J. Org. Chem., 60, 2627 (1995).
• Arylation by aryl iodides is promoted by copper(I) iodide: Synthesis, 67 (1983); J. Org. Chem., 58, 7606 (1993); or trans-Dichlorobis(triphenylphosphine)palladium(II), 10491: Synthesis, 506 (1985).
• For examples of Knoevenagel condensations of cyanoacetic esters with carbonyl compounds, see: Org. Synth. Coll., 3, 385, 399 (1955); 4, 93, 463 (1963); review: Org. React., 15, 204 (1967). Knoevenagel condensation with aromatic aldehydes has also been carried out under acidic conditions, for example, good yields have been obtained with ZnCl₂: Tetrahedron Lett., 32, 5821 (1991).