2,4,6-三异丙基苯磺酰氯

• 产品号: A11458
• CAS号: 6553-96-4
• 分子式: C15H23ClO2S
• 分子量: 302.85992
• 纯 度: 98%

产品别名

• 标题: 2,4,6-Triisopropylbenzenesulfonyl chloride
• IUPAC标准名: 2,4,6-tris(propan-2-yl)benzene-1-sulfonyl chloride
• IUPAC传统名: 2,4,6-triisopropylbenzenesulfonyl chloride
• 别名: Trisyl chloride

产品登记号

• EC号: 229-479-6
• Beilstein号: 1218575
• MDL号: MFCD00007433
• CAS号: 6553-96-4

产品性质

• 纯度: 98%
• 熔点: 94-97°C
• GHS危险声明: H314-H318
• 欧盟危险性物质标志: 腐蚀性(Corrosive) (C)
• GHS警示性声明: P260-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501A
• 危险公开号: 34
• 安全公开号: 20-26-36/37/39-45
• 保存注意事项: Moisture Sensitive
• TSCA收录: 否
• 联合国危险货物等级: 8
• 联合国危险货物编号: UN3096
• 联合国危险货物包装类别(PG): II

参考文献

• Hindered sulfonyl chlorides have found use as condensing agents for the formation of the phosphate link of oligonucleotides. For reviews, see: Angew. Chem. Int. Ed., 11, 451 (1972); Synthesis, 222 (1975); Chem. Rev., 77, 183 (1977). For reviews of oligonucleotide synthesis by the phosphotriester method, see: Heterocycles, 7, 1197 (1977); Tetrahedron, 34, 3143 (1978). For use as a condensing agent in the synthesis of H-phosphonate diesters, see: Nucleosides Nucleotides, 7, 23 (1988). More hindered in comparison with, e.g. Mesitylene-2-sulfonyl chloride, A11775, and so has less tendency to react with the free 5'-hydroxyl group of sugars: J. Am. Chem. Soc., 88, 829 (1966).
• For examples of the utility of the triisopropylbenzenesulfonyl group in the protection of OH groups, see: J. Am. Chem. Soc., 117, 5693, 5776 (1995): (first synthesis of a digitalis saponin and asymmetric synthesis of (-) and (+)-strychnine, respectively).