N,N-二甲基乙酰胺

• 产品号: A10924
• CAS号: 127-19-5
• 分子式: C4H9NO
• 分子量: 87.12036
• 纯 度: 99%

产品别名

• 标题: N,N-Dimethylacetamide
• IUPAC标准名: N,N-dimethylacetamide
• IUPAC传统名: dimethylacetamide
• 别名: DMA

产品登记号

• EC号: 204-826-4
• 默克索引号: 143227
• CAS号: 127-19-5
• Beilstein号: 1737614
• MDL号: MFCD00008686

产品性质

• 纯度: 99%
• 沸点: 165-166°C
• 密度: 0.940
• 闪点: 70°C(158°F)
• 熔点: -20°C
• 折射率: 1.4385
• GHS危险声明: H360-H312-H332-H227
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• GHS警示性声明: P210-P261-P280-P302+P352-P405-P501A
• 危险公开号: 61-20/21
• RTECS编号: AB7700000
• 安全公开号: 53-45
• TSCA收录: 是

参考文献

• Useful solvent in halex fluorinations of chloroarenes; compare Sulfolane, A13466.
• See also Sodium hydride, 13431, for warning.
• Dipolar aprotic solvent, cf N,N-Dimethylformamide, A13547, Dimethyl sulfoxide, A13280, 1-Methyl-2-pyrrolidinone, A12260.
• Undergoes Vilsmeier-type reactions (compare DMF), with reactive substrates, introducing an acetyl group: Chem. Ber., 97, 616 (1964).
• Reacts with alkyl and aryl Grignard reagents to give methyl ketones in good yields: Synthesis, 228 (1984).
• In the presence of triflic anhydride and 2,4,6-collidine, forms a highly-reactive keteniminium triflate, which undergoes a [2+2] cycloaddition reaction with terminal alkenes to give, after hydrolysis a 3-alkylcyclobutanone: J. Am. Chem. Soc., 107, 2192 (1985); Org. Synth. Coll., 8, 306 (1993):