2,2,2-三氟乙醇

• 产品号: A10788
• CAS号: 75-89-8
• 分子式: C2H3F3O
• 分子量: 100.0398296
• 纯 度: 99+%

产品别名

• 标题: 2,2,2-Trifluoroethanol
• IUPAC标准名: 2,2,2-trifluoroethan-1-ol
• IUPAC传统名: trifluoroethanol
• 别名: Trifluoroethyl alcohol

产品登记号

• CAS号: 75-89-8
• MDL号: MFCD00004672
• EC号: 200-913-6
• Beilstein号: 1733203

产品性质

• 纯度: 99+%
• 沸点: 74-75°C
• 密度: 1.391
• 闪点: 29°C(84°F)
• 熔点: -44°C
• 折射率: 1.2900
• GHS危险声明: H301-H311-H331-H315-H335-H318-H226
• 欧盟危险性物质标志: X
• GHS警示性声明: P210-P301+P310-P303+P361+P353-P305+P351+P338-P361-P405-P501A
• 危险公开号: 10-20/21/22-37/38-41
• RTECS编号: KM5250000
• 安全公开号: 9-23-26-36/37/39-60
• TSCA收录: 是
• 联合国危险货物等级: 3
• 联合国危险货物编号: UN1992
• 联合国危险货物包装类别(PG): III

参考文献

• Trifluoroethyl esters have also found use as active esters in peptide coupling; see, for example: J. Chem. Soc., Perkin 1, 2867 (1996).
• Useful ionizing solvent, see: Tetrahedron Lett., 2335 (1974), and references therein. Good solvent for oligopeptides with potential as a cosolvent along with proton acceptors such as DMF for peptide coupling reactions: Tetrahedron Lett., 33, 7007 (1992). Compare 1,1,1,3,3,3-Hexafluoro-2-propanol, A12747.
• Effective solvent for uncatalyzed epoxidations of alkenes with hydrogen peroxide (caution! 60%): Synlett, 248 (2001). For a review of fluorinated alcohols as solvents for selective and clean reactions, see: Synlett, 18 (2004).
• Reacts with triphenylphosphine dibromide to give the bis(trifluoroethoxy)phosphorane, which converts alcohols to trifluoroethyl ethers, carboxylic acids to trifluoroethyl esters and aldehydes to bis(trifluoroethyl) acetals: J. Org. Chem., 45, 5052 (1980).
• The stereodirecting effect of the MEM group (see 2-Methoxyethoxymethyl chloride, L01050) has been exploited by Percy et al in the formation of a new fluorine-containing acyl anion equivalent: Tetrahedron, 51, 9201 (1995):
  
• Claisen or Wittig rearrangements of the derived difluoroallyl alcohols can be used in routes to molecules containing a CF₂ group: Tetrahedron, 51, 11327 (1995); J. Org. Chem., 61, 166 (1996), or to monofluorinated vinylic compounds: Tetrahedron Lett., 37, 5183 (1996).