二氯磷酸苯酯

• 产品号: A10479
• CAS号: 770-12-7
• 分子式: C6H5Cl2O2P
• 分子量: 210.982461
• 纯 度: 97%

产品别名

• 标题: Phenyl phosphorodichloridate
• IUPAC标准名: phenoxyphosphonoyl dichloride
• IUPAC传统名: phenyl dichlorophosphate
• 别名: Phenyl dichlorophosphate

产品登记号

• EC号: 212-220-6
• CAS号: 770-12-7
• Beilstein号: 511863
• MDL号: MFCD00002067

产品性质

• 纯度: 97%
• 沸点: 241-243°C
• 密度: 1.415
• 闪点: 112°C(233°F)
• 熔点: -1°C
• 折射率: 1.5230
• GHS危险声明: H301-H310-H314-H318
• 欧盟危险性物质标志: 剧毒(Highly toxic) (T+)
• GHS警示性声明: P260-P301+P310-P303+P361+P353-P305+P351+P338-P361-P405-P501A
• 危险公开号: 22-27-34
• RTECS编号: TD4393000
• 安全公开号: 26-28-36/37/39-45
• 保存注意事项: Moisture Sensitive
• TSCA收录: 是
• 联合国危险货物等级: 8
• 联合国危险货物编号: UN2922
• 联合国危险货物包装类别(PG): II

参考文献

• Reagent for the preparation of phosphate diesters. The phenyl group is removable by hydrogenolysis: J. Am. Chem. Soc., 75, 4510 (1953).
• Coupling reagent, e.g. in pyridine for the preparation of derivatives of sulfinic acids with alcohols, amines, thiols etc.: Synthesis, 937 (1980). Similarly, carboxylic acids in pyridine can be coupled with thiols to give thiocarboxylic acid S-esters: Can. J. Chem., 58, 2645 (1980), and with sodium azide in the presence of a phase-transfer catalyst to give acyl azides: Synth. Commun., 13, 289 (1983).
• Reacts with the Li enolates of ?-diketones, in the presence of LiCl, to give ?-chloro-ɑ?-enones: Can. J. Chem., 64, 520 (1986).
• In combination with NaI, cleaves dialkyl ethers to iodides in high yield: Synth. Commun., 18, 119 (1988), and 1,3-dithianes and other dithioacetals to carbonyl groups: Tetrahedron Lett., 29, 5471 (1988).
• In combination with Dimethyl sulfoxide, A13280, effects selective oxidation of alcohols to aldehydes or ketones with less ɑ-chlorination than the more usual Swern (Oxalyl chloride, A18012) system: J. Org. Chem., 52, 5621 (1987). Similarly, benzylamines have been converted to benzaldehydes: Synth. Commun., 19, 3407 (1989).
• For a brief feature on uses of the reagent in synthesis, see: Synlett, 1651 (2004).