二异丙胺

• 产品号: A10280
• CAS号: 108-18-9
• 分子式: C6H15N
• 分子量: 101.19
• 纯 度: 99+%

产品别名

• 标题: Diisopropylamine
• IUPAC标准名: bis(propan-2-yl)amine
• IUPAC传统名: diisopropylamine

产品登记号

• MDL号: MFCD00008862
• Beilstein号: 605284
• CAS号: 108-18-9
• EC号: 203-558-5
• 默克索引号: 143196

产品性质

• 纯度: 99+%
• 沸点: 83-84°C
• 密度: 0.718
• 闪点: -7°C(19°F)
• 熔点: -61°C
• 折射率: 1.3920
• GHS危险声明: H225-H314-H318-H302-H332
• 欧盟危险性物质标志: X
• 欧盟危险性物质标志: 腐蚀性(Corrosive) (C)
• 欧盟危险性物质标志: 易燃性(Flammable) (F)
• GHS警示性声明: P210-P241-P303+P361+P353-P305+P351+P338-P405-P501A
• 危险公开号: 11-20/22-34
• RTECS编号: IM4025000
• 安全公开号: 16-26-36/37/39-45
• TSCA收录: 是
• 联合国危险货物等级: 3
• 联合国危险货物编号: UN1158
• 联合国危险货物包装类别(PG): II

参考文献

• Precursor of the sterically-hindered strong base lithium diisopropylamide (LDA), which has a greater "kinetic-basicity" than some thermodynamically stronger bases, e.g. alkyllithiums, and therefore finds wide application in lithiation reactions. LDA is a particularly useful base for the preparation of carboxylic acid dianions and ester enolates. For a review, see: Synthesis, 521 (1982).
• LDA is generally prepared in situ by reaction of diisopropylamine with an alkyllithium; numerous examples in Org. Synth. Coll., 6, 7, 8, 9, and subsequent annual volumes. For discussion of methods for preparation, including Li metal in the presence of an aromatic hydrocarbon as electron-acceptor, see: Synthesis, 463 (1979); see also (Li in ether): Liebigs Ann. Chem., 1471 (1980).
• LDA cleaves 1,3-dithiolanes (ethylene dithioacetals) to the carbonyl compounds: Synthesis, 1087 (1982):
  
• 1,3-Dithianes are not cleaved under these conditions.