甲磺酰氯

• 产品号: A13383
• CAS号: 124-63-0
• 分子式: CH3ClO2S
• 分子量: 114.55132
• 纯 度: 98%

产品别名

• 标题: Methanesulfonyl chloride
• IUPAC标准名: methanesulfonyl chloride
• IUPAC传统名: methanesulfonyl chloride
• 别名: Mesyl chloride

产品登记号

• EC号: 204-706-1
• MDL号: MFCD00007454
• Beilstein号: 506297
• 默克索引号: 145955
• CAS号: 124-63-0

产品性质

• 纯度: 98%
• 沸点: 161°C
• 密度: 1.477
• 闪点: 97°C(206°F)
• 熔点: -33°C
• 折射率: 1.4520
• GHS危险声明: H300-H310-H330-H314-H318
• 欧盟危险性物质标志: 剧毒(Highly toxic) (T+)
• GHS警示性声明: P260-P301+P310-P303+P361+P353-P304+P340-P305+P351+P338-P320-P330-P361-P405-P501A
• 危险公开号: 24/25-26-34
• RTECS编号: PB2790000
• 联合国危险货物包装类别(PG): I
• 安全公开号: 4-9-20-23-26-27-36/37/39-45
• 保存注意事项: Moisture Sensitive
• TSCA收录: 是
• 联合国危险货物等级: 6.1
• 联合国危险货物编号: UN3246

参考文献

• Esters of hindered acids have been prepared via the mesyl mixed anhydride and reaction with the alcohol in the presence of DMAP: Synth. Commun., 12, 727 (1982).
• Reagent for conversion of alcohols to their mesylate esters. For mesylation of an acetylenic alcohol followed by displacement with an amine, see Org. Synth. Coll., 9, 46 (1998). In the presence of triethylamine, reaction occurs by way of the sulfene intermediate, which mesylates alcohols of low nucleophilicity including tert-alcohols and 2,2,2-trifluoroethanol: J. Org. Chem., 35, 3195 (1970).
• In pyridine, primary alcohols are converted to alkyl chlorides, via nucleophilic displacement by Cl^- on the mesylate: Chem. Pharm. Bull., 24, 365 (1976); J. Org. Chem., 48, 657 (1983). In combination with LiCl in collidine, allylic alcohols are converted to chlorides without allylic rearrangement: J. Org. Chem., 36, 3044 (1971).
• For use in the symmetrical coupling of aryl mesylates to give biaryls, catalyzed by Dichlorobis(triphenylphosphine)nickel(II), 13930, see: J. Org. Chem., 60, 6895 (1995).