异氰酸苯酯

• 产品号: A12808
• CAS号: 103-71-9
• 分子式: C7H5NO
• 分子量: 119.1207
• 纯 度: 98+%

产品别名

• 标题: Phenyl isocyanate
• IUPAC标准名: isocyanatobenzene
• IUPAC传统名: phenyl isocyanate

产品登记号

• 默克索引号: 147296
• Beilstein号: 471391
• EC号: 203-137-6
• MDL号: MFCD00001994
• CAS号: 103-71-9

产品性质

• 纯度: 98+%
• 沸点: 62-64°C/11mm
• 密度: 1.094
• 闪点: 51°C(123°F)
• 熔点: -33°C
• 折射率: 1.5360
• GHS危险声明: H301-H330-H317-H334-H314-H318-H226
• 欧盟危险性物质标志: 剧毒(Highly toxic) (T+)
• GHS警示性声明: P210-P301+P310-P303+P361+P353-P304+P340-P305+P351+P338-P320-P330-P405-P501A
• 危险公开号: 10-22-26-34-42/43
• RTECS编号: DA3675000
• 安全公开号: 23-26-28-36/37/39-45
• 保存注意事项: Moisture Sensitive
• TSCA收录: 是
• 联合国危险货物等级: 6.1
• 联合国危险货物编号: UN2487
• 联合国危险货物包装类别(PG): I

参考文献

• For general reactions of isocyanates, see Appendix 3.
• Can be used, in the presence of pyridine, to protect alcohols as N-phenylcarbamates: J. Am. Chem. Soc., 94, 3578 (1972), e.g. selective protection of primary OH groups in pyranosides; cleavage by reduction with LiAlH₄: Tetrahedron Lett., 28, 4165 (1987). The group can also be cleaved by refluxing with NaOMe: Acta Chem. Scand., 15, 87, 96 (1961). Amines may also be protected as N-phenylcarbamates: Tetrahedron Lett., 1935 (1977).
• Forms ureas by reaction with amines; e.g. Tris(2-aminoethyl)amine, B21789, gives a molecule containing three urea groups which was used in studies of spacers for phosphate receptors: Chem. Lett., 759 (1995). Reaction with 4-aminobenzimidazole derivatives has been used in the synthesis of 1-phenylxanthine derivatives: Synthesis, 855 (1995).
• In the presence of triethylamine, dehydrates nitroalkanes to nitrile oxides, which can undergo 1,3-dipolar cycloadditions: J. Am. Chem. Soc., 82, 5339 (1960); Synthesis, 757 (1980). Similarly, aldoximes are converted to nitriles: J. Org. Chem., 26, 782 (1961).
• Conversion to diphenylcarbodiimide can be catalyzed by 3-Methyl-1-phenyl-2-phospholene 1-oxide, A11792: Org. Synth. Coll., 5, 501 (1973).