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2,4-二硝基-1-氟苯_分子结构_CAS_70-34-8)
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2,4-二硝基-1-氟苯

产品号 A11871 公司名称 Alfa Aesar
CAS号 70-34-8 公司网站 http://www.alfa.com
分子式 C6H3FN2O4 电 话
分子量 186.0974232 传 真
纯 度 99% 电子邮件
保 存 Chembase数据库ID: 95166

产品价格信息

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产品别名

标题
1-Fluoro-2,4-dinitrobenzene
IUPAC标准名
1-fluoro-2,4-dinitrobenzene
IUPAC传统名
dinitrofluorobenzene
别名
Sanger's Reagent
2,4-Dinitrofluorobenzene

产品登记号

Beilstein号 398632
CAS号 70-34-8
默克索引号 144172
EC号 200-734-3
MDL号 MFCD00007056

产品性质

纯度 99%
RTECS编号 CZ7800000
安全公开号 24-26-36/37/39-45
GHS危险品标识 GHS05
GHS危险品标识 GHS06
GHS危险品标识 GHS08
GHS危险声明 H301-H311-H331-H315-H317-H318-H341
欧盟危险性物质标志 有毒(Toxic) 有毒(Toxic) (T)
GHS警示性声明 P261-P301+P310-P305+P351+P338-P361-P405-P501A
危险公开号 23/24/25-38-41-43-68
TSCA收录
联合国危险货物等级 6.1
联合国危险货物编号 UN2811
联合国危险货物包装类别(PG) III
沸点 296°C
密度 1.482
闪点 >110°C(230°F)
熔点 24-30°C
折射率 1.5690

产品详细信息

参考文献

  • Has been used as a means of protection for the thiol group. The resulting thioether can be cleaved quantitatively with 2-mercaptoethanol: Biochem. Biophys. Res. Commun., 29, 178 (1967).
  • Can also be used for the masking of the imidazole ring in histidine as the 2,4-dinitrophenyl derivative during peptide synthesis, introduced in the presence of, e.g. K2CO3: Biochem. Biophys. Acta., 82, 412 (1964). The group can be cleaved by treatment with thioglycolic acid, mercaptoethanol, dithiothreitol or thiophenol: Biochem. Biophys. Res. Commun., 29, 178 (1967); Biochemistry, 9, 5122 (1970). The electron withdrawing character of the group has been shown to reduce racemization promoted by the imidazole function: J. Biol. Chem., 247, 4768 (1972). See Appendix 6.
  • The activated fluoro-substituent is readily displaced by nucleophiles under mild conditions. The anomeric center of a carbohydrate has been protected as the 2,4-dinitrophenyl ether in the presence of DABCO in DMF: Rec. Trav. Chim., 99, 355 (1980).
  • Used for labelling terminal amino acids in peptides: Biochem. J., 45, 563 (1949); Biochemistry, 20, 512 (1981).