Phensuximide

• 产品号: DB00832
• CAS号: 86-34-0
• 分子式: C11H11NO2
• 分子量: 189.21054

产品别名

• 标题: Phensuximide
• IUPAC标准名: 1-methyl-3-phenylpyrrolidine-2,5-dione
• IUPAC传统名: N-methyl-2-phenyl succinimide
• 商标名: Milonton; Milontin; (+/-)-N-Methyl-2-phenylsuccinimide; 1-Methyl-3-Phenylsuccinimide; Fensuximida [INN-Spanish]; Epimid; Fenosuccimide; Fensuccimide [DCIT]; Methylphenylsuccinimide; N-Methyl-2-phenylsuccinimide; N-Methyl-alpha-phenolsuccinimide; Phensuximid; Phensuximide [BAN:INN]; Phenylsuximide; Succinimide, N-methyl-2-phenyl-; Succitimal; Lifene; Milontin (TN); Mirontin; Mirotin; 7 Phenosuccimide; N-Methyl-alpha-phenylsuccinimide; Phensuximide (USP); Phensuximidum [INN-Latin]

产品登记号

• PubChem SID: 46505695
• PubChem CID: 6839
• CAS号: 86-34-0

产品性质

• 疏水性(logP): 0.7
• 溶解度: 7020 mg/L

产品详细信息

详细说明 (English)

• Drug Groups: approved
• Description: Phensuximide is an anticonvulsant in the succinimide class. It suppresses the paroxysmal three cycle per second spike and wave EEG pattern associated with lapses of consciousness in petit mal seizures. The frequency of attacks is reduced by depression of nerve transmission in the motor cortex.
• Indication: For the treatment of epilepsy.
• Pharmacology: Phensuximide suppresses the paroxysmal three cycle per second spike and wave EEG pattern associated with lapses of consciousness in absence (petit mal) seizures. The frequency of attacks is reduced by depression of nerve transmission in the motor cortex.
• Affected Organisms: Humans and other mammals
• Biotransformation: Hepatic.
• Absorption: Rapid and complete.
• Protein Binding: 21%
• References: Rankin GO, Cressey-Veneziano K, Wang RT, Brown PI: Urinary tract effects of phensuximide in the Sprague-Dawley and Fischer 344 rat. J Appl Toxicol. 1986 Oct;6(5):349-56. [Pubmed] ; CHEN G, WESTON JK, BRATTON AC Jr: Anticonvulsant activity and toxicity of phensuximide, methsuximide and ethosuximide. Epilepsia. 1963 Mar;4:66-76. [Pubmed] ; Ferrendelli JA, Kinscherf DA: Inhibitory effects of anticonvulsant drugs on cyclic nucleotide accumulation in brain. Ann Neurol. 1979 Jun;5(6):533-8. [Pubmed]
• External Links: Wikipedia

参考文献

• Rankin GO, Cressey-Veneziano K, Wang RT, Brown PI: Urinary tract effects of phensuximide in the Sprague-Dawley and Fischer 344 rat. J Appl Toxicol. 1986 Oct;6(5):349-56. Pubmed
• CHEN G, WESTON JK, BRATTON AC Jr: Anticonvulsant activity and toxicity of phensuximide, methsuximide and ethosuximide. Epilepsia. 1963 Mar;4:66-76. Pubmed
• Ferrendelli JA, Kinscherf DA: Inhibitory effects of anticonvulsant drugs on cyclic nucleotide accumulation in brain. Ann Neurol. 1979 Jun;5(6):533-8. Pubmed