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Trifluoperazine

产品号 DB00831 公司名称 DrugBank
CAS号 117-89-5 公司网站 http://www.ualberta.ca/
分子式 C21H24F3N3S 电 话 (780) 492-3111
分子量 407.4955696 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 710

产品价格信息

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产品别名

标题
Trifluoperazine
IUPAC标准名
10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10H-phenothiazine
IUPAC传统名
trifluoperazine
商标名
Stelazine
Novo-Trifluzine
Tryptazine
Triphtazine
Terfluzine
Eskazinyl
Fluoperazine
Modalina
Triflurin
Triftazine
Triphthasine
Triphthazine
Eskazine
Jatroneural
Stellazine
Synklor
Trazine
Triftazin
Triperazine
Triphtazin
别名
Trifluoperazine Dihydrochloride
Trifluoromethylperazine
Trifluoroperazine
Triphthazine Dihydrochloride
Trifluperazine
Trifluoperazine HCl
Trifluoroperazine Hydrochloride
Trifluoroperazine Dihydrochloride
Trifluoperazine Hydrochloride
Tryptazine Dihydrochloride
Trifluoperazin
Trifluoperazina
Trifluroperizine

产品登记号

PubChem SID 46507961
PubChem CID 5566
CAS号 117-89-5

产品性质

疏水性(logP) 4.9
溶解度 0.0122 mg/mL at 24 oC [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. [PubChem]
Indication For the treatment of anxiety disorders, depressive symptoms secondary to anxiety and agitation.
Pharmacology Trifluoperazine is a trifluoro-methyl phenothiazine derivative intended for the management of schizophrenia and other psychotic disorders. Trifluoperazine has not been shown effective in the management of behaviorial complications in patients with mental retardation.
Toxicity Symptoms of overdose include agitation, coma, convulsions, difficulty breathing, difficulty swallowing, dry mouth, extreme sleepiness, fever, intestinal blockage, irregular heart rate, low blood pressure, and restlessness.
Affected Organisms
Humans and other mammals
Biotransformation Hepatic.
Half Life 10-20 hours
External Links
Wikipedia
RxList
PDRhealth
Drugs.com

参考文献