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Phenmetrazine

产品号 DB00830 公司名称 DrugBank
CAS号 134-49-6 公司网站 http://www.ualberta.ca/
分子式 C11H15NO 电 话 (780) 492-3111
分子量 177.2429 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 709

产品价格信息

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产品别名

标题
Phenmetrazine
IUPAC标准名
3-methyl-2-phenylmorpholine
IUPAC传统名
phenmetrazine
商标名
Neo-zine
Mefolin
Cafilon
Marsin
Phenmetrazin
Probese-P
Psychamine A 66
Psychamine A 66 hydrochloride
Bromadryl
Phenmetrazine hydrochloride
Preludin
Preludin hydrochloride
Probese-P hydrochloride
别名
Oxazimedrine
3-Methyl-2-phenylmorpholine
Phenmetrazinum [INN-Latin]
Fenmetrazina [INN-Spanish]
2-Phenyl-3-Methylmorpholine
Phenmetraline hydrochloride
Defenmetrazin
Fenmetrazin
Dexphenmetrazine
USAF Ge-1

产品登记号

CAS号 134-49-6
PubChem CID 4762
PubChem SID 46504524

产品性质

疏水性(logP) 1.7
溶解度 >5 mg/L

产品详细信息

详细说明 (English)
Item Information
Drug Groups illicit; approved
Description A sympathomimetic drug used primarily as an appetite depressant. Its actions and mechanisms are similar to dextroamphetamine. [PubChem]
Indication Used as an anorectic in the treatment of obesity.
Pharmacology Phenmetrazine is a sympathomimetic drug used primarily as an appetite depressant. Its actions and mechanisms are similar to dextroamphetamine. Amphetamines are non-catecholamine sympathomimetic amines with CNS stimulant activity. Phenmetrazine was originally sold under the tradename Preludin as an anorectic. It has since been removed from the market. It is by some considered to have a greater potential for addiction than the amphetamines, and has been abused in many countries, for example Sweden.
Toxicity Adult monkeys have an LD50 of 15 to 20 mg/kg, whereas for young monkeys the LD50 is only 5 mg/kg. Symptoms of overdose include acute central nervous system stimulation, cardiotoxicity causing tachycardia, arrhythmias, hypertension, and cardiovascular collapse. Whilst some patients show signs of toxicity at blood concentrations of 20 µg/L, chronic abusers of amphetamine have been known to have blood concentration of up to 3000 µg/L.
Affected Organisms
Humans and other mammals
Biotransformation Primarily hepatic (via CYP3A and CYP2D6). Resistant to metabolism by monoamine oxidase. Metabolism involves deamination to para-hydroxyamphetamine and phenylacetone; this latter compound is subsequently oxidize to benzoic acid and excreted as glucuronide or glycine (hippuric acid) conjugate. Smaller amounts of amphetamine are converted to norephedrine by oxidation.
Absorption Readily absorbed from the gastro-intestinal tract and buccal mucosa.
Half Life 16 to 31 hours
External Links
Wikipedia

参考文献