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Fosfomycin

产品号 DB00828 公司名称 DrugBank
CAS号 23155-02-4 公司网站 http://www.ualberta.ca/
分子式 C3H7O4P 电 话 (780) 492-3111
分子量 138.059041 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 707

产品价格信息

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产品别名

标题
Fosfomycin
IUPAC标准名
[(2R,3S)-3-methyloxiran-2-yl]phosphonic acid
IUPAC传统名
fosfomycin
商标名
Veramina
Monurol
别名
phosphomycin disodium salt
Fosfocina
Fosfomycin sodium
Phosphonomycin
Fosfomycin disodium salt
Fosfonomycin
Phosphomycin

产品登记号

CAS号 23155-02-4
PubChem SID 46506665
PubChem CID 446987

产品性质

疏水性(logP) -1.6
溶解度 50 mg/mL (Sodium salt)

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description An antibiotic produced by Streptomyces fradiae. [PubChem]
Indication For the treatment of uncomplicated urinary tract infections (acute cystitis) in women due to susceptible strains of Escherichia coli and Enterococcus faecalis.
Pharmacology Fosfomycin is a broad spectrum antibiotic that concentrates in kidney and bladder and is used to treat uncomplicated urinary tract infections. Fosfomycin also reduces nephrotoxicity and ototoxicity of platinum-containing anti-tumor agents.
Toxicity LD50>5 g/kg (rats). Side effects may include diarrhea
Affected Organisms
Enteric bacteria and other eubacteria
Biotransformation No transformation, excreted unchanged
Absorption Fosfomycin tromethamine is rapidly absorbed following oral administration and converted to fosfomycin. Oral bioavailability under fasting conditions is 37%. When given with food, oral bioavailability is reduced to 30%
Half Life 5.7 (± 2.8) hours. The elimination half-life is 40 hours in anuric patients undergoing hemodialysis.
Protein Binding 0% (not bound to plasma proteins)
Elimination Fosfomycin is excreted unchanged in both urine and feces.
Distribution * 136.1 ±44.1 L
Clearance * 16.9 +/- 3.5 L/hr
External Links
Wikipedia
RxList
PDRhealth
Drugs.com

参考文献