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Natamycin

产品号 DB00826 公司名称 DrugBank
CAS号 7681-93-8 公司网站 http://www.ualberta.ca/
分子式 C33H47NO13 电 话 (780) 492-3111
分子量 665.72518 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 705

产品价格信息

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产品别名

标题
Natamycin
IUPAC标准名
(1R,3S,5R,7R,8E,12R,14E,16E,18E,20E,22R,24S,25R,26S)-22-{[(3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy}-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.0^{5,7}]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid
IUPAC传统名
natamycin
商标名
Natacyn
Pimaricin

产品登记号

PubChem CID 5281099
CAS号 7681-93-8
PubChem SID 46509171

产品性质

疏水性(logP) 1.1
溶解度 4100 mg/L

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description Amphoteric macrolide antifungal antibiotic from Streptomyces natalensis or S. chattanoogensis. It is used for a variety of fungal infections, mainly topically. [PubChem]
Indication For the treatment of fungal blepharitis, conjunctivitis, and keratitis caused by susceptible organisms including Fusarium solani keratitis.
Pharmacology Natamycin is an antifungal drug for topical ophthalmic administration. It is a tetraene polyene antibiotic derived from Streptomyces natalensis. It possesses in vitro activity against a variety of yeast and filamentous fungi, including Candida, Aspergillus, Cephalosporium, Fusarium and Penicillium. Although the activity against fungi is dose-related, natamycin is predominantly fungicidal. Natamycin is not effective in vitro against gram-positive or gram-negative bacteria. Topical administration appears to produce effective concentrations of natamycin within the corneal stroma but not in intraocular fluid.
Affected Organisms
Various Fungus Species
Absorption Systemic absorption should not be expected following topical administration, and as with other polyene antibiotics, absorption from the gastrointestinal tract is very poor.
External Links
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