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L-Phenylalanine

产品号 DB00120 公司名称 DrugBank
CAS号 63-91-2 公司网站 http://www.ualberta.ca/
分子式 C9H11NO2 电 话 (780) 492-3111
分子量 165.18914 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 7

产品价格信息

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产品别名

标题
L-Phenylalanine
IUPAC标准名
(2S)-2-amino-3-phenylpropanoic acid
IUPAC传统名
L-phenylalanine
别名
(S)-alpha-Amino-beta-phenylpropionic acid

产品登记号

CAS号 63-91-2
PubChem CID 6140
PubChem SID 46505708

产品性质

疏水性(logP) -1.4
溶解度 Slight (0.1-1%)

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved; nutraceutical
Description An essential aromatic amino acid that is a precursor of melanin; dopamine; noradrenalin (norepinephrine), and thyroxine. [PubChem]
Indication L-phenylalanine may be helpful in some with depression. It may also be useful in the treatment of vitiligo. There is some evidence that L-phenylalanine may exacerbate tardive dyskinesia in some schizophrenic patients and in some who have used neuroleptic drugs.
Pharmacology Used by the brain to produce Norepinephrine, a chemical that transmits signals between nerve cells and the brain; keeps you awake and alert; reduces hunger pains; functions as an antidepressant and helps improve memory.
Toxicity L-phenylalanine will exacerbate symptoms of phenylketonuria if used by phenylketonurics. L-phenylalanine was reported to exacerbate tardive dyskinesia when used by some with schizophrenia.
Affected Organisms
Humans and other mammals
Biotransformation Hepatic. L-phenylalanine that is not metabolized in the liver is distributed via the systemic circulation to the various tissues of the body, where it undergoes metabolic reactions similar to those that take place in the liver.
Absorption Absorbed from the small intestine by a sodium dependent active transport process.
External Links
Wikipedia
PDRhealth

参考文献