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Rosoxacin

产品号 DB00817 公司名称 DrugBank
CAS号 40034-42-2 公司网站 http://www.ualberta.ca/
分子式 C17H14N2O3 电 话 (780) 492-3111
分子量 294.30466 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 696

产品价格信息

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产品别名

标题
Rosoxacin
IUPAC标准名
1-ethyl-4-oxo-7-(pyridin-4-yl)-1,4-dihydroquinoline-3-carboxylic acid
IUPAC传统名
rosoxacin
商标名
Eradacil
Winuron
Roxadyl
Eracine
Eradacin
别名
Acrosoxacin
Rosoxacino [INN-Spanish]
ROS
Rosoxacine [INN-French]

产品登记号

CAS号 40034-42-2
PubChem SID 46508469
PubChem CID 287180

产品性质

疏水性(logP) 3
溶解度 0.0209 mg/mL at 25 oC [MEYLAN,WM et al. (1996)]

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description Rosoxacin is a quinolone derivative antibiotic for the treatment of bacterial infection of respiratory tract, urinary tract, GI, CNS and immuno compromised patients. Rosoxacin is known to be effective against penicillin resistant strains and is a single dose orally administered drug, which avoids all complications of parenteral administration seen with penicillin, especially anaphylactic shock.
Indication For the treatment of bacterial infection of respiratory tract, urinary tract, GI, CNS and immuno compromised patients.
Pharmacology Rosoxacin is a nonfluorinated quinolone antibiotic. Its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Rosoxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria.
Affected Organisms
Enteric bacteria and other eubacteria

参考文献