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Dicyclomine

产品号 DB00804 公司名称 DrugBank
CAS号 77-19-0 公司网站 http://www.ualberta.ca/
分子式 C19H35NO2 电 话 (780) 492-3111
分子量 309.4867 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 683

产品价格信息

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产品别名

标题
Dicyclomine
IUPAC标准名
2-(diethylamino)ethyl 1-cyclohexylcyclohexane-1-carboxylate
IUPAC传统名
dicyclomine
商标名
Dicycloverine
Kolantyl Hydrochloride
Dicyclomine Hcl
Mamiesan
Dicyclomine Hydrochloride
Diethylaminocarbethoxybicyclohexyl Hydrochloride
Bentyl
Bentylol
Bentylol Hydrochloride
Di-Syntramine
Dicycloverin
Dyspas
Oxityl-P
Procyclomin
Wyovin
Atumin
Bentomine
Bentyl Hydrochloride
Dicicloverina [INN-Spanish]
Dicycloverin Hydrochloride
Dicycloverine Hydrochloride
Dicycloverinum [INN-Latin]
Diocyl
Diocyl Hydrochloride
Formulex
Merbentyl
Sawamin
Spasmoban
Wyovin Hydrochloride

产品登记号

PubChem SID 46505371
CAS号 77-19-0
PubChem CID 3042

产品性质

疏水性(logP) 5.5

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description A muscarinic antagonist used as an antispasmodic and in urinary incontinence. It has little effect on glandular secretion or the cardiovascular system. It does have some local anesthetic properties and is used in gastrointestinal, biliary, and urinary tract spasms. [PubChem]
Indication For the treatment of functional bowel/irritable bowel syndrome
including Colicky abdominal pain; diverticulitis
Pharmacology Dicyclomine is an anticholinergic drug, a medication that reduces the effect of acetylcholine, a chemical released from nerves that stimulates muscles, by blocking the receptors for acetylcholine on smooth muscle (a type of muscle). It also has a direct relaxing effect on smooth muscle. Dicyclomine is used to treat or prevent spasm in the muscles of the gastrointestinal tract in the irritable bowel syndrome. In addition, Dicyclomine inhibits gastrointestinal propulsive motility and decreases gastric acid secretion and controls excessive pharyngeal, tracheal and bronchial secretions.
Affected Organisms
Humans and other mammals
Protein Binding >99%
Elimination The principal route of elimination is via the urine (79.5% of the dose). Excretion also occurs in the feces, but to a lesser extent (8.4%).
Distribution * 3.65 L/kg [20 mg oral dose]
External Links
Wikipedia
RxList
Drugs.com

参考文献