| Item |
Information |
|
Drug Groups
|
approved |
|
Description
|
A synthetic pentapeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid. [PubChem] |
| Indication |
Used as a diagnostic aid for evaluation of gastric acid secretory function |
| Pharmacology |
Pentagastrin is indicated as a diagnostic aid for evaluation of gastric acid secretory function. It is effective in testing for anacidity (achlorhydria) in patients with suspected pernicious anemia, atrophic gastritis, or gastric carcinoma. It is also effective in determining the reduction in acid output after operations for peptic ulcer, such as vagotomy or gastric resection. |
| Affected Organisms |
| • |
Humans and other mammals |
|
| Biotransformation |
Primarily hepatic |
| Absorption |
Rapidly absorbed after parenteral administration. |
| Half Life |
10 minutes or less |
| References |
| • |
Weintraub HS, Rudolph A: Combination Therapy for Managing Difficult-to-Treat Patients With Stage 2 Hypertension: Focus on Valsartan-Based Combinations. Am J Ther. 2010 Jun 9.
[Pubmed]
|
|
| External Links |
|