Item |
Information |
Drug Groups
|
approved |
Description
|
Nitrogen mustard derivative of uracil. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage. [PubChem] |
Indication |
Used for its antineoplastic properties. |
Pharmacology |
Uracil Mustard selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of Uracil Mustard-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed. |
Affected Organisms |
• |
Humans and other mammals |
|
Protein Binding |
5% |
External Links |
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