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Metiamide

产品号 DB08805 公司名称 DrugBank
CAS号 34839-70-8 公司网站 http://www.ualberta.ca/
分子式 C9H16N4S2 电 话 (780) 492-3111
分子量 244.38014 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 6405

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产品别名

标题
Metiamide
IUPAC标准名
3-methyl-1-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl)thiourea
IUPAC传统名
metiamide
别名
Metiamida
Methiamide
Metiamidum

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CAS号 34839-70-8

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产品详细信息

详细说明 (English)
Item Information
Drug Groups experimental
Description Metiamide is a histamine H2-receptor antagonist developed from another H2 antagonist, burimamide. It was an intermediate compound in the development of the successful anti-ulcer drug cimetidine.
Indication Potential in the treatment and the management of acid-reflux disorders (GERD), peptic ulcer disease, heartburn, and acid indigestion.
Pharmacology Metiamide is a histamine H2-receptor antagonist. It reduces basal and nocturnal gastric acid secretion and a reduction in gastric volume, acidity, and amount of gastric acid released in response to stimuli including food, caffeine, insulin, betazole, or pentagastrin. Metiamide inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Metiamide include an increase in gastric bacterial flora such as nitrate-reducing organisms.
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