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Hydroflumethiazide

产品号 DB00774 公司名称 DrugBank
CAS号 135-09-1 公司网站 http://www.ualberta.ca/
分子式 C8H8F3N3O4S2 电 话 (780) 492-3111
分子量 331.2920296 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 654

产品价格信息

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产品别名

标题
Hydroflumethiazide
IUPAC标准名
1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide
IUPAC传统名
hydroflumethiazide
商标名
Hidroalogen
Robezon
Diuredemina
Diurometon
Enjit
Flutizide
Glomerulin
Spandiuril
别名
Dihydroflumethazide
Hydroflumethazide
Hydroflumethizide
Hidroflumetiazid
Trifluoromethylhydrazide
Trifluoromethylhydrothiazide

产品登记号

PubChem CID 3647
PubChem SID 46505220
CAS号 135-09-1

产品性质

疏水性(logP) -0.2
溶解度 0.3 mg/mL at 25 oC [MERCK INDEX (1996)]

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822)
Indication Used as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. Also used in the management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension.
Pharmacology Hydroflumethiazide is an oral thiazide used to treat hypertension and edema. High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. Like other thiazides, Hydroflumethiazide promotes water loss from the body (diuretics). Thiazides inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.
Toxicity Overdoses lead to diuresis, lethargy progressing to coma, with minimal cardiorespiratory depression and with or without significant serum electrolyte changes or dehydration.
Affected Organisms
Humans and other mammals
Biotransformation Essentially unchanged
Absorption Hydroflumethiazide is incompletely but fairly rapidly absorbed from the gastrointestinal tract
Half Life It appears to have a biphasic biological half-life with an estimated alpha-phase of about 2 hours and an estimated beta-phase of about 17 hours
Protein Binding 74%
References
Moser M, Feig PU: Fifty years of thiazide diuretic therapy for hypertension. Arch Intern Med. 2009 Nov 9;169(20):1851-6. [Pubmed]
External Links
RxList

参考文献

  • Moser M, Feig PU: Fifty years of thiazide diuretic therapy for hypertension. Arch Intern Med. 2009 Nov 9;169(20):1851-6. Pubmed