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Malathion

产品号 DB00772 公司名称 DrugBank
CAS号 121-75-5 公司网站 http://www.ualberta.ca/
分子式 C10H19O6PS2 电 话 (780) 492-3111
分子量 330.358021 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 652

产品价格信息

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产品别名

标题
Malathion
IUPAC标准名
1,4-diethyl 2-{[dimethoxy(sulfanylidene)-$l^{5}-phosphanyl]sulfanyl}butanedioate
IUPAC传统名
malathion
商标名
Malathion LV Concentrate
Maltox MLT
Zithiol
Kop-thion
Calmathion
Fyfanon
Carbetox
Detmol MA
Emmatos extra
Ethiolacar
Malakill
Malaspray
Malathion E50
Malathon
Organoderm
Suleo-M
Carbethoxy malathion
Carbetovur
Cleensheen
Cythion
Emmatos
Formal
Forthion
Fosfothion
Fosfotion 550
Hilthion
Hilthion 25WDP
Lice Rid
Malacide
Malafor
Malamar
Malathion 60
Malation
Maltox
Ortho Malathion
Phosphothion
Celthion
Chemathion
Cimexan
Derbac-M
Etiol
Extermathion
Fog 3
Fosfotion
Karbofos
Kop-Thionkypfosmalacide
Kypfos
Latka 4049
Malagran
Malamar 50
Malaphele
Malaphos
Malasol
Malathiozoo
Malatol
Malatox
Malmed
Malphos
Moscarda
OMS 1
Ovide
Prioderm
Sadofos
Sadofos 30
Sadophos
Siptox I
Staeubol-Puder
Sumitox
TAK
Taskil
Vegfru malatox
Vetiol
别名
Mercaptosuccinic acid diethyl ester
Carbofos
Experimental insecticide 4049
Carbophos
Oleophosphothion
Insecticide no. 4049
Compound 4049
Malathione
MLT
Maldison
Mercaptothion
Mercaptotion
malathion

产品登记号

PubChem CID 4004
CAS号 121-75-5
PubChem SID 46505287

产品性质

疏水性(logP) 2
溶解度 143 mg/L

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved; investigational
Description A wide spectrum aliphatic organophosphate insecticide widely used for both domestic and commercial agricultural purposes. [PubChem]
Indication For patients infected with Pediculus humanus capitis (head lice and their ova) of the scalp hair.
Pharmacology Malathion is an organophosphate insecticide commonly used to control mosquitos and other flying insects. Pharmaceutically, malathion is used to eliminate head lice. The principal toxicological effect of malathion is cholinesterase inhibition, due primarily to malaoxon and to phosphorus thionate impurities.
Toxicity Malathion is slightly toxic via the oral route, with reported oral LD50 values of 1000 mg/kg to greater than 10,000 mg/kg in the rat. It is also slightly toxic via the dermal route, with reported dermal LD50 values of greater than 4000 mg/kg in rats. Moderate poisoning can result in chest tightness, difficulty breathing, bradycardia, tachycardia, tremor/ataxia, blurred vision, and confusion. Severe, life-threatening signs include coma, seizures, respiratory arrest, and paralysis. Malathion may also be irritating to the skin and eyes.
Affected Organisms
Head lice
Biotransformation The major metabolites of malathion are the diacid and monoacid metabolites, namely, malathion dicarboxylic acid (DCA) and malathion monocarboxylic acid (MCA). Malaoxon, the active cholinesterase-inhibiting metabolite of malathion, is a minor metabolite. Both malathion and malaoxon are detoxified by carboxyesterases leading to polar, water-soluble compounds that are excreted.
Absorption Malathion in an acetone vehicle has been reported to be absorbed through normal human skin only to the extent of 8% of the applied dose. Absorption may be increased when malathion is applied to damaged skin. Malathion is rapidly and effectively absorbed by practically all routes including the gastrointestinal tract, skin, mucous membranes, and lungs. However, it is readily excreted in the urine, and does not accumulate in organs or tissues.
Half Life 8-24 hours
References
Baker EL Jr, Warren M, Zack M, Dobbin RD, Miles JW, Miller S, Alderman L, Teeters WR: Epidemic malathion poisoning in Pakistan malaria workers. Lancet. 1978 Jan 7;1(8054):31-4. [Pubmed]
Bonner MR, Coble J, Blair A, Beane Freeman LE, Hoppin JA, Sandler DP, Alavanja MC: Malathion exposure and the incidence of cancer in the agricultural health study. Am J Epidemiol. 2007 Nov 1;166(9):1023-34. Epub 2007 Aug 23. [Pubmed]
Edwards JW, Lee SG, Heath LM, Pisaniello DL: Worker exposure and a risk assessment of malathion and fenthion used in the control of Mediterranean fruit fly in South Australia. Environ Res. 2007 Jan;103(1):38-45. Epub 2006 Aug 17. [Pubmed]
External Links
Wikipedia
RxList
Drugs.com

参考文献

  • Baker EL Jr, Warren M, Zack M, Dobbin RD, Miles JW, Miller S, Alderman L, Teeters WR: Epidemic malathion poisoning in Pakistan malaria workers. Lancet. 1978 Jan 7;1(8054):31-4. Pubmed
  • Bonner MR, Coble J, Blair A, Beane Freeman LE, Hoppin JA, Sandler DP, Alavanja MC: Malathion exposure and the incidence of cancer in the agricultural health study. Am J Epidemiol. 2007 Nov 1;166(9):1023-34. Epub 2007 Aug 23. Pubmed
  • Edwards JW, Lee SG, Heath LM, Pisaniello DL: Worker exposure and a risk assessment of malathion and fenthion used in the control of Mediterranean fruit fly in South Australia. Environ Res. 2007 Jan;103(1):38-45. Epub 2006 Aug 17. Pubmed