Flunisolide

• 产品号: DB00180
• CAS号: 3385-03-3
• 分子式: C24H31FO6
• 分子量: 434.4977432

产品别名

• 标题: Flunisolide
• IUPAC标准名: (1S,2S,4R,8S,9S,11S,12S,13R,19S)-19-fluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosa-14,17-dien-16-one
• IUPAC传统名: flunisolide
• 商标名: Bronalide; Rhinalar; Lunis; Synaclyn; Aerobid; Nasalide; Nasarel; Syntaris
• 别名: Flunisolide [anhydrous]; flunisolide

产品登记号

• CAS号: 3385-03-3
• PubChem CID: 82153
• PubChem SID: 46507894

产品性质

• 疏水性(logP): 1.1
• 溶解度: Practically insoluble

产品详细信息

详细说明 (English)

• Drug Groups: approved; investigational
• Description: Flunisolide (marketed as AeroBid, Nasalide, Nasarel) is a corticosteroid often prescribed as treatment for allergic rhinitis.; ; The principle mechanism of action of flunisolide is to activate glucocorticoid receptors. It also has anti-inflammatory action.
• Indication: For the maintenance treatment of asthma as a prophylactic therapy.
• Pharmacology: Flunisolide is a synthetic corticosteroid. It is administered either as an oral metered-dose inhaler for the treatment of asthma or as a nasal spray for treating allergic rhinitis. Corticosteroids are naturally occurring hormones that prevent or suppress inflammation and immune responses. When given as an intranasal spray, flunisolide reduces watery nasal discharge (rhinorrhea), nasal congestion, postnasal drip, sneezing, and itching oat the back of the throat that are common allergic symptoms.
• Affected Organisms: Humans and other mammals
• Biotransformation: Primarily hepatic, converted to the S beta-OH metabolite.
• Absorption: Absorbed rapidly
• Half Life: 1.8 hours
• Protein Binding: Approximately 40% after oral inhalation
• External Links: Wikipedia; RxList; PDRhealth; Drugs.com