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Benzquinamide

产品号 DB00767 公司名称 DrugBank
CAS号 63-12-7 公司网站 http://www.ualberta.ca/
分子式 C22H32N2O5 电 话 (780) 492-3111
分子量 404.49988 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 647

产品价格信息

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产品别名

标题
Benzquinamide
IUPAC标准名
3-(diethylcarbamoyl)-9,10-dimethoxy-1H,2H,3H,4H,6H,7H,11bH-pyrido[2,1-a]isoquinolin-2-yl acetate
IUPAC传统名
benzquinamide
商标名
Promecon
Emeticon
BZQ
Benzchinamide
Emete-con
Quantril

产品登记号

PubChem CID 2342
PubChem SID 46506155
CAS号 63-12-7

产品性质

疏水性(logP) 1.7
溶解度 153 mg/L

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description Benzquinamide is an antiemetic compound with antihistaminic, mild anticholinergic, and sedative properties. The mechanism of action is not known, but presumably benzquinamide works via antagonism of muscarinic acetycholine receptors and histamine H1 receptors.
Indication Used to prevent and treat nausea and vomiting associated with anesthesia and surgery, administered intramuscularly or intravenously.
Pharmacology Benzquinamide is an antiemetic compound with antihistaminic, mild anticholinergic, and sedative properties.
Affected Organisms
Humans and other mammals
Absorption Incomplete, with 33–39% bioavailability via the capsule and suppository routes, relative to the intramuscular route.
Half Life 1-1.6 hours (for all formulations)

参考文献