| Item |
Information |
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Drug Groups
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approved |
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Description
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A histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness. [PubChem] |
| Indication |
For the prevention and treatment of nausea, vomiting, or dizziness associated with motion sickness. |
| Pharmacology |
Meclizine, a piperazine-derivative H1-receptor antagonist similar to buclizine, cyclizine, and hydroxyzine, is used as an antivertigo/antiemetic agent. Meclizine is used in the management of nausea, vomiting, and dizziness associated with motion sickness and vertigo in diseases affecting the vestibular apparatus. |
| Toxicity |
Symptoms of overdose include drowsiness and anticholinergic effects. LD50=mg/kg (orally in rat). |
| Affected Organisms |
| • |
Humans and other mammals |
|
| Biotransformation |
Hepatic |
| Absorption |
Well absorbed |
| Half Life |
6 hours |
| External Links |
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