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Clodronate

产品号 DB00720 公司名称 DrugBank
CAS号 10596-23-3 公司网站 http://www.ualberta.ca/
分子式 CH4Cl2O6P2 电 话 (780) 492-3111
分子量 244.892382 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 601

产品价格信息

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产品别名

标题
Clodronate
IUPAC标准名
[dichloro(phosphono)methyl]phosphonic acid
IUPAC传统名
clodronate
商标名
Dichloromethanediphosphonic acid
Loron
Acide Clodronique [INN-French]
Bonefos
Ostac
Acido Clodronico [INN-Spanish]
Acidum Clodronicum [INN-Latin]
Clasteon
Dichloromethylidene diphosphonate
别名
clodronate

产品登记号

CAS号 10596-23-3
PubChem CID 25419
PubChem SID 46508646

产品性质

疏水性(logP) -2.4
溶解度 395 mg/L

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved; investigational
Description A diphosphonate which affects calcium metabolism. It inhibits bone resorption and soft tissue calcification. [PubChem]
Indication For the management of hypercalcemia of malignancy and as an adjunct in the management of osteolysis resulting from bone metastases of malignant tumors.
Pharmacology Clodronate is a first generation (non-nitrogenous) bisphosphonate in the same family as etidronate and tiludronate. Clodronate affects calcium metabolism and inhibits bone resorption and soft tissue calcification. Of the clodronate that is resorbed (from oral preparation) or infused (for intravenous drugs), about 50% is excreted unchanged by the kidney. The remainder has a very high affinity for bone tissue, and is rapidly absorbed onto the bone surface. Clodronate has been shown to prevent or delay skeletal-related events and decrease bone pain as well as normalize calcium levels in the presence of hypercalcemia.
Toxicity Decreases in serum calcium following substantial overdosage may be expected in some patients. Signs and symptoms of hypocalcemia also may occur in some of these patients.
Affected Organisms
Humans and other mammals
Biotransformation Clodronate is not metabolized in humans.
Absorption After oral administration, absorption is estimated at 1–3% of the ingested dose because of the low uptake from the gastrointestinal tract.
Half Life Approximately 13 hours.
Protein Binding 2%-36%
External Links
Wikipedia

参考文献