您当前所在的位置:首页 > 产品中心 > 产品信息
Nicergoline_分子结构_CAS_27848-84-6)
点击图片或这里关闭

Nicergoline

产品号 DB00699 公司名称 DrugBank
CAS号 27848-84-6 公司网站 http://www.ualberta.ca/
分子式 C24H26BrN3O3 电 话 (780) 492-3111
分子量 484.38554 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 581

产品价格信息

请登录

产品别名

标题
Nicergoline
IUPAC标准名
[(2S,4R,7R)-2-methoxy-6,11-dimethyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(16),9,12,14-tetraen-4-yl]methyl 5-bromopyridine-3-carboxylate
IUPAC传统名
nicergoline
商标名
Nargoline
Nicergolin [German]
Nicotergoline
Sermion
MNE
Nicergolina [Dcit]
Nicergoline [Usan:Ban:Inn:Jan]
Nicergolinum [INN-Latin]
Nimergoline
Nimergoline Base
Vasospan

产品登记号

CAS号 27848-84-6
PubChem SID 46508741
PubChem CID 34040

产品性质

疏水性(logP) 3.3

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description An ergot derivative that has been used as a cerebral vasodilator and in peripheral vascular disease. It has been suggested to ameliorate cognitive deficits in cerebrovascular disease. [PubChem]
Indication For the treatment of senile dementia, migraines of vascular origin, transient ischemia, platelet hyper-aggregability, and macular degeneration.
Pharmacology Nicergoline is a potent vasodilator (improves brain blood flow). On the cerebral level it prompts a lowering of vascular resistance, an increase in arterial flow and stimulates the use of oxygen and glucose. Nicergoline also improves blood circulation in the lungs and limbs and has been shown to inhibit blood platelet aggregation.
Affected Organisms
Humans and other mammals
References
Winblad B, Fioravanti M, Dolezal T, Logina I, Milanov IG, Popescu DC, Solomon A: Therapeutic use of nicergoline. Clin Drug Investig. 2008;28(9):533-52. [Pubmed]
External Links
Wikipedia

参考文献

  • Winblad B, Fioravanti M, Dolezal T, Logina I, Milanov IG, Popescu DC, Solomon A: Therapeutic use of nicergoline. Clin Drug Investig. 2008;28(9):533-52. Pubmed