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Furosemide

产品号 DB00695 公司名称 DrugBank
CAS号 54-31-9 公司网站 http://www.ualberta.ca/
分子式 C12H11ClN2O5S 电 话 (780) 492-3111
分子量 330.74414 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 577

产品价格信息

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产品别名

标题
Furosemide
IUPAC标准名
4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbenzoic acid
IUPAC传统名
furosemide
商标名
Discoid
Macasirool
Hydrenox
Diumide-K
Diurolasa
Rusyde
Aisemide
Beronald
Dryptal
Frumex
Lasemid
Lasix Special
Lazix
Nelsix
Novosemide
Rosis
Spirofur
Synephron
Aquasin
Diural
Fluss
Frusemin
Fuluvamine
Furesis
Furomen
Furorese
Furose
Furosix
Furoter
Furovite
Less Diur
Lowpston
Lowpstron
Luscek
Polysquall A
Salinex
Selectofur
Urex-M
Yidoli
Apo-Frusemide
Arasemide
Bioretic
Bristab
Bristurin
Disal
Diuzol
Dranex
Durafurid
Edenol
Farsix
Franyl
Frumide
Frumil
Frusema
Frusid
Fulsix
Furantril
Furetic
Furex
Furo-Basan
Furo-Puren
Furodrix
Furosan
Furosemix
Furosifar
Fursol
Hydro
Hydro-Rapid
Impugan
Jenafusid
Kutrix
Lasilix
Liside
Marsemide
Myrosemide
Nadis
Prefemin
Promedes
Radouna
Rosemide
Sal Diureticum
Salurid
Trofurit
Urian
Aldalix
Aldic
Aluzine
Anfuramaide
Apo-Furosemide
Aquarid
Cetasix
Depix
Desal
Desdemin
Di-Ademil
Dirine
Disemide
Diurapid
Diuretic Salt
Diusemide
Diusil
Edemid
Eliur
Elodrine
Endural
Errolon
Eutensin
Finuret
Fluidrol
Frusedan
Frusenex
Frusetic
Fuluvamide
Furanthril
Furanthryl
Furanturil
Furfan
Furix
Furmid
Furobeta
Furocot
Furodiurol
Furomex
Furomide M.D.
Furosedon
Furoside
Fusid
Golan
Hissuflux
Hydol
Hydrex
Hydroled
Katlex
Kofuzon
Kolkin
Lasiletten
Lasix
Lasix Retard
Leodrine
Logirene
Mirfat
Mita
Moilarorin
Neo-Renal
Octan Draselny
Odemase
Odemex
Olmagran
Profemin
Promide
Protargen
Puresis
Radisemide
Radonna
Retep
Rodiuran
Rontyl
Salix
Salurex
Saluron
Seguril
Sigasalur
Sisuril
Transit
Uremide
Uresix
Urex
Uridon
Uritol
Urosemide
Vergonil
Vesix
Diucardin
Diurin
Lasex
Laxur
Oedemex
Zafimida
别名
Furosemida [INN-Spanish]
Furosemid
Frusemide
Fursemid
Fursemida
Frusemid
Dihydroflumethiazide
Furosemidu [Polish]
Furosemidum [INN-Latin]
Fursemide
Methforylthiazidine
Metflorylthiazidine

产品登记号

PubChem SID 46506779
CAS号 54-31-9
PubChem CID 3440

产品性质

疏水性(logP) 1.4
溶解度 0.006 mg/mL

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for edema and chronic renal insufficiency. [PubChem]
Indication For the treatment of edema associated with congestive heart failure, cirrhosis of the liver, and renal disease, including the nephrotic syndrome. Also for the treatment of hypertension alone or in combination with other antihypertensive agents.
Pharmacology Furosemide, a sulfonamide-type loop diuretic structurally related to bumetanide, is used to manage hypertension and edema associated with congestive heart failure, cirrhosis, and renal disease, including the nephrotic syndrome.
Toxicity Profound diuresis may cause fluid and electrolyte depletion. Excessive dehydration and potassium depletion may occur. Excessive diuresis may cause rapid weight loss, orthostatic hypotension or acute hypotensive episodes. May also cause tinnitus, reversible or permanent hearing loss or reversible deafness.
Affected Organisms
Humans and other mammals
Biotransformation Only a small amount is hepatically metabolized to the defurfurylated derivative, 4-chloro-5-sulfamoylanthranilic acid.
Absorption 60% absorbed in patients with normal renal function
Half Life 2 hours
Protein Binding 95% bound to plasma proteins
Elimination Furosemide is excreted in urine. Significantly more furosemide is excreted in urine following the I.V. injection than after the tablet or oral solution.
References
Rais-Bahrami K, Majd M, Veszelovszky E, Short BL: Use of furosemide and hearing loss in neonatal intensive care survivors. Am J Perinatol. 2004 Aug;21(6):329-32. [Pubmed]
Korpi ER, Kuner T, Seeburg PH, Luddens H: Selective antagonist for the cerebellar granule cell-specific gamma-aminobutyric acid type A receptor. Mol Pharmacol. 1995 Feb;47(2):283-9. [Pubmed]
Tia S, Wang JF, Kotchabhakdi N, Vicini S: Developmental changes of inhibitory synaptic currents in cerebellar granule neurons: role of GABA(A) receptor alpha 6 subunit. J Neurosci. 1996 Jun 1;16(11):3630-40. [Pubmed]
Wafford KA, Thompson SA, Thomas D, Sikela J, Wilcox AS, Whiting PJ: Functional characterization of human gamma-aminobutyric acidA receptors containing the alpha 4 subunit. Mol Pharmacol. 1996 Sep;50(3):670-8. [Pubmed]
External Links
Wikipedia
RxList
Drugs.com

参考文献

  • Rais-Bahrami K, Majd M, Veszelovszky E, Short BL: Use of furosemide and hearing loss in neonatal intensive care survivors. Am J Perinatol. 2004 Aug;21(6):329-32. Pubmed
  • Korpi ER, Kuner T, Seeburg PH, Luddens H: Selective antagonist for the cerebellar granule cell-specific gamma-aminobutyric acid type A receptor. Mol Pharmacol. 1995 Feb;47(2):283-9. Pubmed
  • Tia S, Wang JF, Kotchabhakdi N, Vicini S: Developmental changes of inhibitory synaptic currents in cerebellar granule neurons: role of GABA(A) receptor alpha 6 subunit. J Neurosci. 1996 Jun 1;16(11):3630-40. Pubmed
  • Wafford KA, Thompson SA, Thomas D, Sikela J, Wilcox AS, Whiting PJ: Functional characterization of human gamma-aminobutyric acidA receptors containing the alpha 4 subunit. Mol Pharmacol. 1996 Sep;50(3):670-8. Pubmed