| Item |
Information |
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Drug Groups
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approved |
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Description
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A phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium, such as the aqueous humor, and is used therapeutically as a diagnostic aid in corneal injuries and corneal trauma. It has been approved by FDA for use in externally applied drugs and cosmetics. (From Merck Index, 12th ed; American Medical Association Drug Evaluations; 1995, p2275) |
| Indication |
For diagnostic imaging. Primarily indicated in diagnostic fluorescein angiography or angioscopy of the fundus and of the iris vasculature. |
| Affected Organisms |
| • |
Humans and other mammals |
|
| Absorption |
Rapidly distributed |
| Protein Binding |
85% |
| Elimination |
Fluorescein and its metabolites are mainly eliminated via renal excretion. |
| Distribution |
* 0.5 L/kg |
| Clearance |
* renal cl=1.75 mL/min/kg [After IV administration]
* hepatic cl=1.50 mL/min/kg [After IV administration] |
| References |
| • |
Noga EJ, Udomkusonsri P: Fluorescein: a rapid, sensitive, nonlethal method for detecting skin ulceration in fish. Vet Pathol. 2002 Nov;39(6):726-31.
[Pubmed]
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| External Links |
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