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Cephaloglycin

产品号 DB00689 公司名称 DrugBank
CAS号 3577-01-3 公司网站 http://www.ualberta.ca/
分子式 C18H19N3O6S 电 话 (780) 492-3111
分子量 405.42496 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 571

产品价格信息

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产品别名

标题
Cephaloglycin
IUPAC标准名
(6R,7R)-3-[(acetyloxy)methyl]-7-[(2R)-2-amino-2-phenylacetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
IUPAC传统名
cephaloglycin
商标名
D-Cephaloglycine
CEG
Cefaloglicina [INN-Spanish]
Cefaloglycin
Cefaloglycine [INN-French]
Cefaloglycinum [INN-Latin]
Cephaloglycin anhydrous
Cephaloglycine
Cephaoglycin acid
Kafocin
Kefglycin

产品登记号

PubChem SID 46506850
CAS号 3577-01-3
PubChem CID 19150

产品性质

疏水性(logP) -0.3
溶解度 154 mg/L

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description A cephalorsporin antibiotic. [PubChem]
Indication For treatment of severe infections caused by susceptible bacteria.
Pharmacology Cephaloglycin is an antibiotic related to cephalosporin but no longer in common use. It is an orally absorbed derivative of cephalosporin C.
Toxicity Adverse effects following overdosage include nausea, vomiting, epigastric distress, diarrhea, and convulsions.
Affected Organisms
Enteric bacteria and other eubacteria
Absorption Well absorbed following oral administration.
References
Tune BM, Hsu CY: The renal mitochondrial toxicity of beta-lactam antibiotics: in vitro effects of cephaloglycin and imipenem. J Am Soc Nephrol. 1990 Nov;1(5):815-21. [Pubmed]
Tune BM, Fravert D, Hsu CY: Oxidative and mitochondrial toxic effects of cephalosporin antibiotics in the kidney. A comparative study of cephaloridine and cephaloglycin. Biochem Pharmacol. 1989 Mar 1;38(5):795-802. [Pubmed]
External Links
Wikipedia

参考文献

  • Tune BM, Hsu CY: The renal mitochondrial toxicity of beta-lactam antibiotics: in vitro effects of cephaloglycin and imipenem. J Am Soc Nephrol. 1990 Nov;1(5):815-21. Pubmed
  • Tune BM, Fravert D, Hsu CY: Oxidative and mitochondrial toxic effects of cephalosporin antibiotics in the kidney. A comparative study of cephaloridine and cephaloglycin. Biochem Pharmacol. 1989 Mar 1;38(5):795-802. Pubmed