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Amphotericin B

产品号 DB00681 公司名称 DrugBank
CAS号 1397-89-3 公司网站 http://www.ualberta.ca/
分子式 C47H73NO17 电 话 (780) 492-3111
分子量 924.07902 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 563

产品价格信息

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产品别名

标题
Amphotericin B
IUPAC标准名
(1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-{[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy}-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
IUPAC传统名
amphotericin B
商标名
Amphozone
ABLC
Ampho-Moronal
Fungisone
AmB
Abelcet
AmBisome
Amphocin
Amphotec
Amphotericin
Fungilin
Fungizone Intravenous
Mysteclin-F
Tegopen
Fungizone
HSDB 3008 IAB
Halizon
IAB
LNS-AmB
SinuNase
别名
AMPH-B
Amphortericin B
Amphotericine B
Liposomal Amphotericin B
amphotericin B

产品登记号

PubChem CID 5280965
PubChem SID 46505473
CAS号 1397-89-3

产品性质

疏水性(logP) 0.8
溶解度 750 mg/L

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved; investigational
Description Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses.
Indication Used to treat potentially life threatening fungal infections.
Pharmacology Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses.
Toxicity Oral, rat: LD50 = >5 gm/kg. Amphotericin B overdoses can result in cardio-respiratory arrest.
Affected Organisms
Various Fungus Species
Biotransformation Exclusively renal
Absorption Bioavailability is 100% for intravenous infusion.
Half Life An elimination half-life of approximately 15 days follows an initial plasma half-life of about 24 hours.
Protein Binding Highly bound (>90%) to plasma proteins.
Clearance * 39 +/- 22 mL/hr/kg [febrile neutropenic cancer and bone marrow transplant patients receiving infusion of 1 mg/kg/day at Day 1]
* 17 +/- 6 mL/hr/kg [febrile neutropenic cancer and bone marrow transplant patients receiving infusion of 1 mg/kg/day 3-20 days later]
* 51 +/- 44 mL/hr/kg [febrile neutropenic cancer and bone marrow transplant patients receiving infusion of 2.5 mg/kg/day at Day 1]
* 22 +/- 15 mL/hr/kg [febrile neutropenic cancer and bone marrow transplant patients receiving infusion of 2.5 mg/kg/day 3-20 days later]
* 21 +/- 14 mL/hr/kg [febrile neutropenic cancer and bone marrow transplant patients receiving infusion of 5 mg/kg/day at Day 1]
* 11 +/- 6 mL/hr/kg [febrile neutropenic cancer and bone marrow transplant patients receiving infusion of 5 mg/kg/day 3-20 days later]
External Links
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