Benzyl Benzoate

• 产品号: DB00676
• CAS号: 120-51-4
• 分子式: C14H12O2
• 分子量: 212.24388

产品别名

• 标题: Benzyl Benzoate
• IUPAC标准名: benzyl benzoate
• IUPAC传统名: benzyl benzoate
• 商标名: Scobenol; Vanzoate; Venzonate; Benzyl alcohol benzoic ester; Ascabiol; Benylate; Benzoic acid benzyl ester; Benzoic acid, benzyl ester; Benzyl ester; Benzylester kyseliny benzoove; Colebenz; Novoscabin; Scabagen; Scabanca; Scabide; Ascabin; Benzoic acid, phenylmethyl ester; Benzyl benzenecarboxylate; Benzyl benzoate 99+ %; Benzyl phenylformate; Benzylets; Peruscabin; Scabiozon; Scabitox; Venzoate

产品登记号

• PubChem SID: 46508023
• CAS号: 120-51-4
• PubChem CID: 2345

产品性质

• 疏水性(logP): 3.7
• 溶解度: 15.4 mg/L

产品详细信息

详细说明 (English)

• Drug Groups: approved
• Description: Benzyl benzoate is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite sarcoptes scabiei. It is characterised by severe itching (particularly at night), red spots, and may lead to a secondary infection. Benzyl benzoate is lethal to this mite and so is useful in the treatment of scabies. It is also used to treat lice infestation of the head and body. Benzyl benzoate is not the treatment of choice for scabies due to its irritant properties.
• Indication: Used to kill lice and the mites responsible for the skin condition scabies.
• Pharmacology: Benzyl benzoate is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite sarcoptes scabiei. It is characterised by severe itching (particularly at night), red spots, and may lead to a secondary infection. Benzyl benzoate is lethal to this mite and so is useful in the treatment of scabies. It is also used to treat lice infestation of the head and body. Benzyl benzoate is not the treatment of choice for scabies due to its irritant properties.
• Toxicity: Oral, rabbit: LD₅₀ = 1680 mg/kg; Skin, rabbit: LD₅₀ = 4000 mg/kg. Symptoms of overdose include blister formation, crusting, itching, oozing, reddening, or scaling of skin; difficulty in urinating (dribbling); jerking movements; sudden loss of consciousness.
• Affected Organisms: Sarcoptes scabiei
• Biotransformation: Rapidly hydrolyzed to benzoic acid and benzyl alcohol, which is further oxidized to benzoic acid. The benzoic acid is conjugated with glycine to form hippuric acid.
• Absorption: No data are available on percutaneous absorption of benzyl benzoate. Some older studies have suggested some percutaneous absorption, however the amount was not quantified.
• References: Bachewar NP, Thawani VR, Mali SN, Gharpure KJ, Shingade VP, Dakhale GN: Comparison of safety, efficacy, and cost effectiveness of benzyl benzoate, permethrin, and ivermectin in patients of scabies. Indian J Pharmacol. 2009 Feb;41(1):9-14. [Pubmed] ; Buffet M, Dupin N: Current treatments for scabies. Fundam Clin Pharmacol. 2003 Apr;17(2):217-25. [Pubmed]
• External Links: Wikipedia; Drugs.com

参考文献

• Buffet M, Dupin N: Current treatments for scabies. Fundam Clin Pharmacol. 2003 Apr;17(2):217-25. Pubmed
• Bachewar NP, Thawani VR, Mali SN, Gharpure KJ, Shingade VP, Dakhale GN: Comparison of safety, efficacy, and cost effectiveness of benzyl benzoate, permethrin, and ivermectin in patients of scabies. Indian J Pharmacol. 2009 Feb;41(1):9-14. Pubmed